Paola Sebastiani
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Explore the profile of Paola Sebastiani including associated specialties, affiliations and a list of published articles.
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190
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5829
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Recent Articles
1.
Kuchel G, Hevener A, Ruby J, Sebastiani P, Kumar V
J Gerontol A Biol Sci Med Sci
. 2025 Mar;
80(4).
PMID: 40052564
Historically, aging research has focused primarily on the study of differences in means of varied measures obtained at different ages. However, growing evidence has shown that for many parameters, variability...
2.
Liu A, Jacobs-McFarlane C, Sebastiani P, Glassberg J, McCuskee S, Curtis S
Ann Hematol
. 2025 Feb;
PMID: 39969536
Plasma free hemoglobin (PFH) is a direct biomarker for hemolysis that has been associated with clinical complications such as pulmonary hypertension and death in patients with sickle cell disease (SCD)....
3.
Rogina B, Anderson R, LeBrasseur N, Curan S, Yousefzadeh M, Ghosh B, et al.
J Gerontol A Biol Sci Med Sci
. 2025 Feb;
PMID: 39932386
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic...
4.
Xiang Q, Lok J, Roth N, Andersen S, Perls T, Song Z, et al.
medRxiv
. 2025 Jan;
PMID: 39802799
Background: Recent studies have revealed a strong association between the e2 allele of the Apolipoprotein E ( gene and lipid metabolites. In addition, carriers appear to be protected from cognitive...
5.
Hummer B, Sebastiani P, Leshchyk A, Gurinovich A, Bager C, Karsdal M, et al.
bioRxiv
. 2025 Jan;
PMID: 39763916
Dupuytren Disease (DD) is a chronic progressive disease that can cause disabling hand deformities. The most common treatments have high rates of complications and early recurrence. Dupuytren lacks a staging...
6.
Gurinovich A, Song Z, Bae H, Leshchyk A, Li M, Lords H, et al.
Geroscience
. 2025 Jan;
PMID: 39751714
Using whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted...
7.
Ellis D, Watanabe K, Wilmanski T, Lustgarten M, Ardisson Korat A, Glusman G, et al.
bioRxiv
. 2024 Nov;
PMID: 39605362
Apolipoprotein E ( ) modifies human aging; specifically, the ε2 and ε4 alleles are among the strongest genetic predictors of longevity and Alzheimer's disease (AD) risk, respectively. However, detailed mechanisms...
8.
Sebastiani P, Monti S, Lustgarten M, Song Z, Ellis D, Tian Q, et al.
Cell Rep
. 2024 Nov;
43(11):114913.
PMID: 39504246
Metabolites that mark aging are not fully known. We analyze 408 plasma metabolites in Long Life Family Study participants to characterize markers of age, aging, extreme longevity, and mortality. We...
9.
Dowrey T, Cranston S, Skvir N, Lok Y, Gould B, Petrowitz B, et al.
Aging Cell
. 2024 Sep;
24(1):e14351.
PMID: 39319670
Centenarians provide a unique lens through which to study longevity, healthy aging, and resiliency. Moreover, models of human aging and resilience to disease that allow for the testing of potential...
10.
Camarda N, Lu Q, Meola D, Man J, Song Z, Travers R, et al.
Clin Sci (Lond)
. 2024 Sep;
138(18):1131-1150.
PMID: 39282930
Vascular endothelial growth factor receptor inhibitors (VEGFRis) improve cancer survival but are associated with treatment-limiting hypertension, often attributed to endothelial cell (EC) dysfunction. Using phosphoproteomic profiling of VEGFRi-treated ECs, drugs...