L Adrienne Cupples
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Explore the profile of L Adrienne Cupples including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Orchard P, Blackwell T, Kachuri L, Castaldi P, Cho M, Christenson S, et al.
medRxiv
. 2025 Mar;
PMID: 40034763
Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we...
2.
Xu H, Gupta S, Dinsmore I, Kollu A, Cawley A, Anwar M, et al.
medRxiv
. 2024 Jun;
PMID: 38903089
Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could...
3.
Keener R, Chhetri S, Connelly C, Taub M, Conomos M, Weinstock J, et al.
Nat Commun
. 2024 May;
15(1):4417.
PMID: 38789417
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere...
4.
Kavousi M, Bos M, Barnes H, Lino Cardenas C, Wong D, Lu H, et al.
Nat Genet
. 2023 Sep;
55(10):1651-1664.
PMID: 37770635
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention....
5.
Tobias D, Manning A, Wessel J, Raghavan S, Westerman K, Bick A, et al.
Diabetes Care
. 2023 Sep;
46(11):1978-1985.
PMID: 37756531
Objective: Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion. CHIP presence has been implicated in atherosclerotic coronary...
6.
Zhang X, Brody J, Graff M, Highland H, Chami N, Xu H, et al.
medRxiv
. 2023 Sep;
PMID: 37662265
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European...
7.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
8.
Liu J, Xu H, Cupples L, O Connor G, Liu C
Ann Hum Genet
. 2023 Apr;
87(4):174-183.
PMID: 37009668
Introduction: Observational studies have shown that body mass index (BMI) and waist-to-hip ratio (WHR) are both inversely associated with lung function, as assessed by forced vital capacity (FVC) and forced...
9.
Young K, Fisher V, Deng X, Brody J, Graff M, Lim E, et al.
HGG Adv
. 2022 Dec;
4(1):100163.
PMID: 36568030
Anthropometric traits, measuring body size and shape, are highly heritable and significant clinical risk factors for cardiometabolic disorders. These traits have been extensively studied in genome-wide association studies (GWASs), with...
10.
Li X, Quick C, Zhou H, Gaynor S, Liu Y, Chen H, et al.
Nat Genet
. 2022 Dec;
55(1):154-164.
PMID: 36564505
Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes. Existing...