Clint De Nolf
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Explore the profile of Clint De Nolf including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
65
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Recent Articles
1.
Delvenne A, Vandendriessche C, Gobom J, Burgelman M, Dujardin P, De Nolf C, et al.
Fluids Barriers CNS
. 2024 Jul;
21(1):58.
PMID: 39020361
Background: Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer's disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely...
2.
Vetters J, van Helden M, De Nolf C, Rennen S, Cloots E, Van de Velde E, et al.
iScience
. 2024 Jan;
26(12):108570.
PMID: 38162021
The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been...
3.
Reuschle Q, Van Heddegem L, Bosteels V, Moncan M, Depauw S, Wadier N, et al.
J Autoimmun
. 2023 Dec;
142:103152.
PMID: 38071801
Anti-nuclear antibodies are the hallmark of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma. However, the molecular mechanisms of B cell tolerance breakdown in these pathological contexts are...
4.
Xie J, Bruggeman A, De Nolf C, Vandendriessche C, Van Imschoot G, Van Wonterghem E, et al.
EMBO J
. 2023 Jul;
42(17):e111515.
PMID: 37427561
Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of gut microbiota on...
5.
Flores-Santibanez F, Rennen S, Fernandez D, De Nolf C, Van de Velde E, Gaete Gonzalez S, et al.
Front Immunol
. 2023 Jun;
14:1209588.
PMID: 37346037
In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells. However, the...
6.
Claeys W, Van Hoecke L, Lernout H, De Nolf C, Van Imschoot G, Van Wonterghem E, et al.
J Neuroinflammation
. 2023 May;
20(1):130.
PMID: 37248507
Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present. The interplay between hyperammonemia and inflammation...
7.
Bosteels V, Marechal S, De Nolf C, Rennen S, Maelfait J, Tavernier S, et al.
Sci Immunol
. 2023 May;
8(83):eadd3955.
PMID: 37172103
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways...
8.
Cloots E, Simpson M, De Nolf C, Lencer W, Janssens S, Grey M
Mucosal Immunol
. 2021 Jun;
14(6):1235-1246.
PMID: 34075183
Barrier epithelial cells lining the mucosal surfaces of the gastrointestinal and respiratory tracts interface directly with the environment. As such, these tissues are continuously challenged to maintain a healthy equilibrium...