Evolution and Function of the Epithelial Cell-specific ER Stress Sensor IRE1β

Overview

Journal Mucosal Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2021 Jun 2

PMID 34075183

Citations 17

Authors

Eva Cloots

Mariska S Simpson

Clint De Nolf

Wayne I Lencer

Sophie Janssens

Michael J Grey

Affiliations

Soon will be listed here.

Abstract

Barrier epithelial cells lining the mucosal surfaces of the gastrointestinal and respiratory tracts interface directly with the environment. As such, these tissues are continuously challenged to maintain a healthy equilibrium between immunity and tolerance against environmental toxins, food components, and microbes. An extracellular mucus barrier, produced and secreted by the underlying epithelium plays a central role in this host defense response. Several dedicated molecules with a unique tissue-specific expression in mucosal epithelia govern mucosal homeostasis. Here, we review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1α. IRE1β arose through gene duplication in early vertebrates and adopted functions unique from IRE1α which appear to underlie the basic development and physiology of mucosal tissues.

Citing Articles

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Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers.

Dawes S, Hurst N, Grey G, Wieteska L, Wright N, Manfield I Life Sci Alliance. 2024; 7(10).

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