Sofie Rennen
Overview
Explore the profile of Sofie Rennen including associated specialties, affiliations and a list of published articles.
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6
Citations
68
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Recent Articles
1.
Vetters J, van Helden M, De Nolf C, Rennen S, Cloots E, Van de Velde E, et al.
iScience
. 2024 Jan;
26(12):108570.
PMID: 38162021
The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been...
2.
Janssens S, Rennen S, Agostinis P
Immunol Rev
. 2023 Dec;
321(1):350-370.
PMID: 38093416
Dendritic cells (DCs) are myeloid cells bridging the innate and adaptive immune system. By cross-presenting tumor-associated antigens (TAAs) liberated upon spontaneous or therapy-induced tumor cell death to T cells, DCs...
3.
Flores-Santibanez F, Rennen S, Fernandez D, De Nolf C, Van de Velde E, Gaete Gonzalez S, et al.
Front Immunol
. 2023 Jun;
14:1209588.
PMID: 37346037
In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells. However, the...
4.
Bosteels V, Marechal S, De Nolf C, Rennen S, Maelfait J, Tavernier S, et al.
Sci Immunol
. 2023 May;
8(83):eadd3955.
PMID: 37172103
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways...
5.
Poncet A, Bosteels V, Hoffmann E, Chehade S, Rennen S, Huot L, et al.
EMBO Rep
. 2021 Feb;
22(3):e49617.
PMID: 33586853
The unfolded protein response (UPR) has emerged as a central regulator of immune cell responses in several pathologic contexts including infections. However, how intracellular residing pathogens modulate the UPR in...
6.
Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, et al.
Nat Immunol
. 2020 Mar;
21(4):381-387.
PMID: 32205881
Protein ubiquitination regulates protein stability and modulates the composition of signaling complexes. A20 is a negative regulator of inflammatory signaling, but the molecular mechanisms involved are ill understood. Here, we...