Cliff J Luke
Overview
Explore the profile of Cliff J Luke including associated specialties, affiliations and a list of published articles.
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45
Citations
982
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Recent Articles
1.
Dawson Z, Sundaramoorthi H, Regmi S, Zhang B, Morrison S, Fielder S, et al.
Autophagy Rep
. 2024 Jul;
3(1).
PMID: 39070663
Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders. is a useful model organism for studying the...
2.
Yang F, Suo M, Weli H, Wong M, Junidi A, Cummings C, et al.
Cell Rep
. 2023 Nov;
42(11):113394.
PMID: 37950870
The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis. While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to lysis, suggesting that the action...
3.
Lanik W, Luke C, Nolan L, Gong Q, Frazer L, Rimer J, et al.
JCI Insight
. 2023 Mar;
8(8).
PMID: 36881475
Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut...
4.
Zhu G, Wilhelm S, George L, Cassidy B, Zino S, Luke C, et al.
Gut
. 2023 Jan;
72(7):1340-1354.
PMID: 36631248
Objective: Increasing evidence implicates mutation-induced protein misfolding and endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The paucity of animal models harbouring genetic risk variants has hampered...
5.
Greenberg Z, Paracatu L, Monlish D, Dong Q, Rettig M, Roundy N, et al.
Blood
. 2022 Dec;
141(10):1180-1193.
PMID: 36542833
The hematopoietic stem cell (HSC) cycle responds to inflammatory and other proliferative stressors; however, these cells must quickly return to quiescence to avoid exhaustion and maintain their functional integrity. The...
6.
Wang S, Luke C, Pak S, Shi V, Chen L, Moore J, et al.
Commun Biol
. 2022 Jan;
5(1):46.
PMID: 35022555
The endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies. High serum SERPINB3 is prognostic for recurrence...
7.
Luke C, Markovina S, Good M, Wight I, Thomas B, Linneman J, et al.
Commun Biol
. 2022 Jan;
5(1):47.
PMID: 35022507
Lysosomal membrane permeabilization (LMP) and cathepsin release typifies lysosome-dependent cell death (LDCD). However, LMP occurs in most regulated cell death programs suggesting LDCD is not an independent cell death pathway,...
8.
Mihi B, Gong Q, Nolan L, Gale S, Goree M, Hu E, et al.
Cell Rep Med
. 2021 Jul;
2(6):100320.
PMID: 34195684
Necrotizing enterocolitis (NEC) is a deadly intestinal inflammatory disorder that primarily affects premature infants and lacks adequate therapeutics. Interleukin (IL)-22 plays a critical role in gut barrier maintenance, promoting epithelial...
9.
Hu J, Yang P, Wegner D, Heins H, Luke C, Li F, et al.
Hum Mutat
. 2020 Mar;
41(7):1298-1307.
PMID: 32196812
ABCA3 transports phospholipids across lamellar body membranes in pulmonary alveolar type II cells and is required for surfactant assembly. Rare, biallelic, pathogenic ABCA3 variants result in lethal neonatal respiratory distress...
10.
Seiler K, Bajinting A, Alvarado D, Traore M, Binkley M, Goo W, et al.
Sci Rep
. 2020 Mar;
10(1):3842.
PMID: 32123209
The development and physiologic role of small intestine (SI) vasculature is poorly studied. This is partly due to a lack of targetable, organ-specific markers for in vivo studies of two...