Cliff J Luke
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Explore the profile of Cliff J Luke including associated specialties, affiliations and a list of published articles.
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45
Citations
982
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Recent Articles
11.
Song Z, Huang G, Paracatu L, Grimes D, Gu J, Luke C, et al.
Blood
. 2020 Jan;
135(12):891-903.
PMID: 31951647
Leukocyte reduced NADP (NADPH) oxidase plays a key role in host defense and immune regulation. Genetic defects in NADPH oxidase result in chronic granulomatous disease (CGD), characterized by recurrent bacterial...
12.
Orvedahl A, McAllaster M, Sansone A, Dunlap B, Desai C, Wang Y, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(33):16497-16506.
PMID: 31346084
Host inflammatory responses must be tightly regulated to ensure effective immunity while limiting tissue injury. IFN gamma (IFNγ) primes macrophages to mount robust inflammatory responses. However, IFNγ also induces cell...
13.
Thomas B, Wight I, Chou W, Moreno M, Dawson Z, Homayouni A, et al.
PLoS One
. 2019 Mar;
14(3):e0214257.
PMID: 30913273
Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy. The use of Aequorea victoria...
14.
Lanik W, Xu L, Luke C, Hu E, Agrawal P, Liu V, et al.
J Vis Exp
. 2018 Mar;
(132).
PMID: 29553558
Human small intestinal enteroids are derived from the crypts and when grown in a stem cell niche contain all of the epithelial cell types. The ability to establish human enteroid...
15.
Markovina S, Wang S, Henke L, Luke C, Pak S, DeWees T, et al.
Br J Cancer
. 2017 Nov;
118(1):72-78.
PMID: 29112685
Background: Pretreatment serum squamous cell carcinoma antigen (SCCA) is a prognostic biomarker in women with cervical cancer. SCCA has not been evaluated as an early indicator of response to chemoradiation...
16.
Drummond C, Bolock A, Ma C, Luke C, Good M, Coyne C
Proc Natl Acad Sci U S A
. 2017 Feb;
114(7):1672-1677.
PMID: 28137842
Enteroviruses are among the most common viral infectious agents of humans and are primarily transmitted by the fecal-oral route. However, the events associated with enterovirus infections of the human gastrointestinal...
17.
Shi S, Luke C, Miedel M, Silverman G, Kleyman T
J Biol Chem
. 2016 May;
291(27):14012-14022.
PMID: 27189943
Mechanotransduction in Caenorhabditis elegans touch receptor neurons is mediated by an ion channel formed by MEC-4, MEC-10, and accessory proteins. To define the role of these subunits in the channel's...
18.
Cummings E, OReilly L, King D, Silverman R, Miedel M, Luke C, et al.
PLoS One
. 2015 Oct;
10(10):e0141542.
PMID: 26512890
α1-antitrypsin deficiency (ATD) predisposes patients to both loss-of-function (emphysema) and gain-of-function (liver cirrhosis) phenotypes depending on the type of mutation. Although the Z mutation (ATZ) is the most prevalent cause...
19.
Niehaus J, Miedel M, Good M, Wyatt A, Pak S, Silverman G, et al.
Biochemistry
. 2015 Oct;
54(45):6756-9.
PMID: 26497600
The clade B/intracellular serpins protect cells from peptidase-mediated injury by forming covalent complexes with their targets. SERPINB12 is expressed in most tissues, especially at cellular interfaces with the external environment....
20.
Luke C, OReilly L
Curr Protoc Cytom
. 2015 Oct;
74:12.41.1-12.41.17.
PMID: 26423692
Caenorhabditis elegans is a powerful model organism for studying human biology and disease due to its surprisingly high genetic homology to Homo sapiens. Its genetic amenability, small size, short generation...