Claus Scheidereit
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Explore the profile of Claus Scheidereit including associated specialties, affiliations and a list of published articles.
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55
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3145
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Recent Articles
21.
Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, et al.
Nat Commun
. 2015 Jul;
6:7367.
PMID: 26170170
The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNFα mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ∼ 3,800...
22.
Yilmaz Z, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, et al.
Cell Rep
. 2014 Dec;
9(5):1756-1769.
PMID: 25482563
The mechanisms that govern proteolytic maturation or complete destruction of the precursor proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however, they remain poorly understood. Using...
23.
Kreher S, Bouhlel M, Cauchy P, Lamprecht B, Li S, Grau M, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(42):E4513-22.
PMID: 25288773
Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis,...
24.
Hinz M, Scheidereit C
EMBO Rep
. 2013 Dec;
15(1):46-61.
PMID: 24375677
The IκB kinase (IKK) complex is the signal integration hub for NF-κB activation. Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ),...
25.
Nogai H, Wenzel S, Hailfinger S, Grau M, Kaergel E, Seitz V, et al.
Blood
. 2013 Jul;
122(13):2242-50.
PMID: 23869088
Constitutive activation of the nuclear factor-κ B (NF-κB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-κB regulators that...
26.
Hinz M, Arslan S, Scheidereit C
Immunol Rev
. 2012 Mar;
246(1):59-76.
PMID: 22435547
The inhibitory IκB proteins have been discovered as fundamental regulators of the inducible transcription factor nuclear factor-κB (NF-κB). As a generally excepted model, stimulus-dependent destruction of inhibitory IκBs and processing...
27.
Arslan S, Scheidereit C
PLoS One
. 2011 Oct;
6(10):e26069.
PMID: 22016814
Death receptor-induced programmed necrosis is regarded as a secondary death mechanism dominating only in cells that cannot properly induce caspase-dependent apoptosis. Here, we show that in cells lacking TGFβ-activated Kinase-1...
28.
Jing H, Kase J, Dorr J, Milanovic M, Lenze D, Grau M, et al.
Genes Dev
. 2011 Oct;
25(20):2137-46.
PMID: 21979374
In malignancies, enhanced nuclear factor-κB (NF-κB) activity is largely viewed as an oncogenic property that also confers resistance to chemotherapy. Recently, NF-κB has been postulated to participate in a senescence-associated...
29.
Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C
Mol Cell
. 2010 Oct;
40(1):63-74.
PMID: 20932475
As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and the kinase ataxia telangiectasia mutated (ATM) act as proximal...
30.
Stilmann M, Hinz M, Arslan S, Zimmer A, Schreiber V, Scheidereit C
Mol Cell
. 2009 Nov;
36(3):365-78.
PMID: 19917246
Upon genotoxic stresses, cells activate IkappaB kinases (IKKs) and the transcription factor NF-kappaB to modulate apoptotic responses. The SUMO-1 ligase PIASy and the kinase ataxia talengiectasia mutated (ATM) have been...