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Friedrich C Luft

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Articles 654
Citations 14170
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Recent Articles
1.
Sommerfeld R, Ermler P, Fehr J, Bergner B, Lopez D, Sanoff S, et al.
BMJ Nutr Prev Health . 2025 Jan; 7(2):e000949. PMID: 39882292
Background: In the early 1940s, before antihypertensive drugs were available, the Rice Diet Programme (RDP) was developed to treat severe hypertension and, later, diabetes and obesity. Despite significant advancements in...
2.
Kulow V, Roegner K, Labes R, Kasim M, Mathia S, Czopek C, et al.
Acta Physiol (Oxf) . 2024 Oct; 241(1):e14242. PMID: 39422260
Aim: 2,3-bisphosphoglycerate mutase (BPGM) is traditionally recognized for its role in modulating oxygen affinity to hemoglobin in erythrocytes. Recent transcriptomic analyses, however, have indicated a significant upregulation of BPGM in...
3.
Luft F
Hypertension . 2024 Oct; 81(12):2395-2406. PMID: 39355912
Hypertension requires increased systemic vascular resistance. Thus far, Mendelian hypertension-related genes are related to salt retention, an indirect regulatory effect. With the identification of mutated, overactive, PDE3A (phosphodiesterase 3A), we...
4.
Ertuglu L, Sahinoz M, Alsouqi A, Deger S, Guide A, Pike M, et al.
Physiol Rep . 2024 Jul; 12(13):e16127. PMID: 38960895
Background And Aims: High tissue sodium accumulation and intermuscular adipose tissue (IMAT) are associated with aging, type 2 diabetes, and chronic kidney disease. In this study, we aim to investigate...
5.
Marton A, Saffari S, Rauh M, Sun R, Nagel A, Linz P, et al.
J Am Coll Cardiol . 2024 Apr; 83(15):1386-1398. PMID: 38599715
Background: Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due to their osmotic diuretic potential. Objectives: The goal of this study was to test the hypothesis that vasopressin-driven...
6.
Tsvetkov D, Schleifenbaum J, Wang Y, Kassmann M, Polovitskaya M, Ali M, et al.
Hypertension . 2024 Feb; 81(3):561-571. PMID: 38354270
Background: Small arteries exhibit resting tone, a partially contracted state that maintains arterial blood pressure. In arterial smooth muscle cells, potassium channels control contraction and relaxation. Perivascular adipose tissue (PVAT)...
7.
Aydin A, Klenk C, Nemec K, Isbilir A, Martin L, Zauber H, et al.
Life Sci Alliance . 2024 Feb; 7(4). PMID: 38331475
Brachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses, and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein (PTHrP) has been shown to be responsible in all...
8.
Chu Z, Kassmann M, Anistan Y, Luft F, Gollasch M, Tsvetkov D
STAR Protoc . 2024 Jan; 5(1):102845. PMID: 38294910
The isolated perfused kidney is a classic ex vivo preparation for studying renal physiology in general and vascular function. Here, we present a protocol for assessing myogenic tone in isolated...
9.
Luft F
Acta Physiol (Oxf) . 2024 Jan; 240(3):e14084. PMID: 38214031
Aim: To place the consequences of calcineurin inhibition in a cardiovascular context. Methods: Literature review coupled with personal encounters. Results: Calcineurin is a calcium-binding and calmodulin-binding protein that is conserved...
10.
Luft F
Semin Nephrol . 2023 Oct; 43(3):151426. PMID: 37862743
The good old days were not good, at least in terms of treating patients with type 2 diabetes. In the 1960s, the development of a radioimmunoassay for insulin permitted determination...