Claus Scheidereit
Overview
Explore the profile of Claus Scheidereit including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
3145
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Recent Articles
1.
Kolesnichenko M, Scheidereit C
Signal Transduct Target Ther
. 2024 Jul;
9(1):179.
PMID: 39069543
No abstract available.
2.
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, et al.
Nat Commun
. 2023 Nov;
14(1):6947.
PMID: 37935654
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements...
3.
Konrath F, Willenbrock M, Busse D, Scheidereit C, Wolf J
iScience
. 2023 Oct;
26(10):107917.
PMID: 37817938
The activation of IKK/NF-κB by genotoxic stress is a crucial process in the DNA damage response. Due to the anti-apoptotic impact of NF-κB, it can affect cell-fate decisions upon DNA...
4.
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors
Mucka P, Lindemann P, Bosco B, Willenbrock M, Radetzki S, Neuenschwander M, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1303-1312.e3.
PMID: 37506701
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit NF-κB activation...
5.
TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation
Tufan A, Lazarow K, Kolesnichenko M, Sporbert A, von Kries J, Scheidereit C
EMBO J
. 2022 Sep;
41(21):e110372.
PMID: 36124865
In a genome-wide screening for components of the dsDNA-break-induced IKK-NF-κB pathway, we identified scores of regulators, including tumor susceptibility gene TSG101. TSG101 is essential for DNA damage-induced formation of cellular...
6.
Brischetto C, Krieger K, Klotz C, Krahn I, Kunz S, Kolesnichenko M, et al.
Development
. 2021 Nov;
148(21).
PMID: 34751748
Although the role of the transcription factor NF-κB in intestinal inflammation and tumor formation has been investigated extensively, a physiological function of NF-κB in sustaining intestinal epithelial homeostasis beyond inflammation...
7.
Busch K, Kny M, Huang N, Klassert T, Stock M, Hahn A, et al.
J Cachexia Sarcopenia Muscle
. 2021 Sep;
12(6):1653-1668.
PMID: 34472725
Background: Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin-1β (IL-1β), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting Nlrp3 would...
8.
Kolesnichenko M, Mikuda N, Hopken U, Kargel E, Uyar B, Tufan A, et al.
EMBO J
. 2021 Jan;
40(6):e104296.
PMID: 33459422
The IκB kinase (IKK)-NF-κB pathway is activated as part of the DNA damage response and controls both inflammation and resistance to apoptosis. How these distinct functions are achieved remained unknown....
9.
Mothes J, Ipenberg I, Arslan S, Benary U, Scheidereit C, Wolf J
Front Physiol
. 2020 Aug;
11:896.
PMID: 32848849
Signaling pathways involve complex molecular interactions and are controled by non-linear regulatory mechanisms. If details of regulatory mechanisms are not fully elucidated, they can be implemented by different, equally reasonable...
10.
Dembny P, Newman A, Singh M, Hinz M, Szczepek M, Kruger C, et al.
JCI Insight
. 2020 Apr;
5(7).
PMID: 32271161
Although human endogenous retroviruses (HERVs) represent a substantial proportion of the human genome and some HERVs, such as HERV-K(HML-2), are reported to be involved in neurological disorders, little is known...