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» Authors » Claudine Darnault

Claudine Darnault

Explore the profile of Claudine Darnault including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 20
Citations 905
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Juan C Fontecilla-Camps
Anne Volbeda
Patricia Amara
Oriane Renoux
Dominique Bourgeois
Juan Carlos Fontecilla-Camps
Oceane Gigarel
Sandrine Ollagnier de Choudens
Debora Reichmann
Philippe Carpentier
Published In
J Am Chem Soc
Structure
Sci Adv
Immunity
J Biol Chem
Affiliations
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Recent Articles
1.
Structural basis of bacteriophage T5 infection trigger and cell wall perforation
Linares R, Arnaud C, Effantin G, Darnault C, Epalle N, Boeri Erba E, et al.
Sci Adv . 2023 Mar; 9(12):eade9674. PMID: 36961893
Most bacteriophages present a tail allowing host recognition, cell wall perforation, and viral DNA channeling from the capsid to the infected bacterium cytoplasm. The majority of tailed phages bear a...
2.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination
Saez Cabodevilla J, Volbeda A, Hamelin O, Latour J, Gigarel O, Clemancey M, et al.
Chem Commun (Camb) . 2019 Mar; 55(26):3725-3728. PMID: 30855610
Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of...
3.
Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues
Volbeda A, Pellicer Martinez M, Crack J, Amara P, Gigarel O, Munnoch J, et al.
J Am Chem Soc . 2019 Jan; 141(6):2367-2375. PMID: 30657661
The recently discovered Rrf2 family transcriptional regulator RsrR coordinates a [2Fe-2S] cluster. Remarkably, binding of the protein to RsrR-regulated promoter DNA sequences is switched on and off through the facile...
4.
Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA
Volbeda A, Saez Cabodevilla J, Darnault C, Gigarel O, Han T, Renoux O, et al.
ACS Chem Biol . 2018 Apr; 13(5):1209-1217. PMID: 29641168
NadA is a multifunctional enzyme that condenses dihydroxyacetone phosphate (DHAP) with iminoaspartate (IA) to generate quinolinic acid (QA), the universal precursor of the nicotinamide adenine dinucleotide (NAD(P)) cofactor. Using X-ray...
5.
Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
Volbeda A, Dodd E, Darnault C, Crack J, Renoux O, Hutchings M, et al.
Nat Commun . 2017 Apr; 8:15052. PMID: 28425466
NsrR from Streptomyces coelicolor (Sc) regulates the expression of three genes through the progressive degradation of its [4Fe-4S] cluster on nitric oxide (NO) exposure. We report the 1.95 Å resolution...
6.
Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product
Volbeda A, Darnault C, Renoux O, Reichmann D, Amara P, de Choudens S, et al.
J Am Chem Soc . 2016 Aug; 138(36):11802-9. PMID: 27545412
The enzyme NadA catalyzes the synthesis of quinolinic acid (QA), the precursor of the universal nicotinamide adenine dinucleotide (NAD) cofactor. Here, we report the crystal structures of complexes between the...
7.
The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium
Volbeda A, Darnault C, Renoux O, Nicolet Y, Fontecilla-Camps J
Sci Adv . 2015 Dec; 1(11):e1501086. PMID: 26665177
The structure of the dimeric holo-fumarate and nitrate reduction regulator (FNR) from Aliivibrio fischeri has been solved at 2.65 Å resolution. FNR globally controls the transition between anaerobic and aerobic...
8.
The crystal structure of Fe₄S₄ quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad
Cherrier M, Chan A, Darnault C, Reichmann D, Amara P, de Choudens S, et al.
J Am Chem Soc . 2014 Mar; 136(14):5253-6. PMID: 24650327
Quinolinate synthase (NadA) is a Fe4S4 cluster-containing dehydrating enzyme involved in the synthesis of quinolinic acid (QA), the universal precursor of the essential nicotinamide adenine dinucleotide (NAD) coenzyme. A previously...
9.
Crystal structure of the O(2)-tolerant membrane-bound hydrogenase 1 from Escherichia coli in complex with its cognate cytochrome b
Volbeda A, Darnault C, Parkin A, Sargent F, Armstrong F, Fontecilla-Camps J
Structure . 2012 Dec; 21(1):184-190. PMID: 23260654
We report the 3.3 Å resolution structure of dimeric membrane-bound O(2)-tolerant hydrogenase 1 from Escherichia coli in a 2:1 complex with its physiological partner, cytochrome b. From the short distance...
10.
X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli
Volbeda A, Amara P, Darnault C, Mouesca J, Parkin A, Roessler M, et al.
Proc Natl Acad Sci U S A . 2012 Mar; 109(14):5305-10. PMID: 22431599
The crystal structure of the membrane-bound O(2)-tolerant [NiFe]-hydrogenase 1 from Escherichia coli (EcHyd-1) has been solved in three different states: as-isolated, H(2)-reduced, and chemically oxidized. As very recently reported for...