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Oriane Renoux

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Recent Articles
1.
Volbeda A, Saez Cabodevilla J, Darnault C, Gigarel O, Han T, Renoux O, et al.
ACS Chem Biol . 2018 Apr; 13(5):1209-1217. PMID: 29641168
NadA is a multifunctional enzyme that condenses dihydroxyacetone phosphate (DHAP) with iminoaspartate (IA) to generate quinolinic acid (QA), the universal precursor of the nicotinamide adenine dinucleotide (NAD(P)) cofactor. Using X-ray...
2.
Liu W, Amara P, Mouesca J, Ji X, Renoux O, Martin L, et al.
J Am Chem Soc . 2018 Jan; 140(4):1365-1371. PMID: 29300094
Regiospecific dehydration of vicinal diols by enzymes is a difficult reaction that usually requires activation by dedicated organic cofactors. The enzymatic use of radical-based chemistry is an effective but challenging...
3.
Volbeda A, Dodd E, Darnault C, Crack J, Renoux O, Hutchings M, et al.
Nat Commun . 2017 Apr; 8:15052. PMID: 28425466
NsrR from Streptomyces coelicolor (Sc) regulates the expression of three genes through the progressive degradation of its [4Fe-4S] cluster on nitric oxide (NO) exposure. We report the 1.95 Å resolution...
4.
Volbeda A, Darnault C, Renoux O, Reichmann D, Amara P, de Choudens S, et al.
J Am Chem Soc . 2016 Aug; 138(36):11802-9. PMID: 27545412
The enzyme NadA catalyzes the synthesis of quinolinic acid (QA), the precursor of the universal nicotinamide adenine dinucleotide (NAD) cofactor. Here, we report the crystal structures of complexes between the...
5.
Volbeda A, Darnault C, Renoux O, Nicolet Y, Fontecilla-Camps J
Sci Adv . 2015 Dec; 1(11):e1501086. PMID: 26665177
The structure of the dimeric holo-fumarate and nitrate reduction regulator (FNR) from Aliivibrio fischeri has been solved at 2.65 Å resolution. FNR globally controls the transition between anaerobic and aerobic...