Christopher S Hughes
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Explore the profile of Christopher S Hughes including associated specialties, affiliations and a list of published articles.
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30
Citations
1628
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Recent Articles
1.
Takemon Y, Pleasance E, Gagliardi A, Hughes C, Csizmok V, Wee K, et al.
Genome Med
. 2024 Nov;
16(1):136.
PMID: 39578878
Background: Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. Methods: Here, we computationally map genetic...
2.
Pozner A, Li L, Verma S, Wang S, Barrott J, Nelson M, et al.
Nat Commun
. 2024 Feb;
15(1):1165.
PMID: 38326311
The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to...
3.
Pozner A, Verma S, Li L, Wang S, Barrott J, Nelson M, et al.
bioRxiv
. 2023 Oct;
PMID: 37873234
The t(X,17) chromosomal translocation, generating the ASPSCR1-TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCC), frustrating efforts to...
4.
Mooney B, Negri G, Shyp T, Delaidelli A, Zhang H, Spencer Miko S, et al.
Clin Cancer Res
. 2023 Oct;
30(5):1022-1037.
PMID: 37812652
Purpose: Ewing sarcoma is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. Although the survival rate of patients diagnosed with...
5.
Zhang H, Delaidelli A, Javed S, Turgu B, Morrison T, Hughes C, et al.
Sci Adv
. 2023 Aug;
9(34):eadg6693.
PMID: 37611092
amplification () is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However, whether genes within or in close proximity to the amplicon also contribute to NB remains...
6.
Takemon Y, Leblanc V, Song J, Chan S, Lee S, Trinh D, et al.
Cancers (Basel)
. 2023 Jun;
15(10).
PMID: 37345142
encodes a transcriptional repressor and MAPK signalling effector that is inactivated by loss-of-function mutations in several cancer types, consistent with a role as a tumour suppressor. Here, we used bioinformatic,...
7.
Johnson F, Hughes C, Liu A, Lockwood W, Morin G
STAR Protoc
. 2023 Mar;
4(1):102012.
PMID: 36856765
Identification of effector targets is imperative to the characterization of the mechanisms of action of novel small molecules. Here, we describe steps to identify effector drug-protein interactions in lysates derived...
8.
Asleh K, Negri G, Spencer Miko S, Colborne S, Hughes C, Wang X, et al.
Nat Commun
. 2022 Feb;
13(1):896.
PMID: 35173148
Despite advances in genomic classification of breast cancer, current clinical tests and treatment decisions are commonly based on protein level information. Formalin-fixed paraffin-embedded (FFPE) tissue specimens with extended clinical outcomes...
9.
Allen G, Panasenko O, Villanyi Z, Zagatti M, Weiss B, Pagliazzo L, et al.
Cell Rep
. 2021 Sep;
36(9):109633.
PMID: 34469733
In this work, we show that Not4 and Not5 from the Ccr4-Not complex modulate translation elongation dynamics and change ribosome A-site dwelling occupancy in a codon-dependent fashion. These codon-specific changes...
10.
Zhang H, Hughes C, Li W, He J, Surdez D, El-Naggar A, et al.
Cancer Discov
. 2021 May;
11(11):2884-2903.
PMID: 34021002
Cancer cells must overcome anoikis (detachment-induced death) to successfully metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 receptor accessory protein (IL1RAP) to suppress anoikis. IL1RAP is directly...