Christopher M Rice
Overview
Explore the profile of Christopher M Rice including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
618
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Recent Articles
1.
Zakrzewski P, Rice C, Fleming K, Cela D, Groves S, Ponce-Garcia F, et al.
EMBO Rep
. 2025 Feb;
PMID: 39962231
Barth syndrome (BTHS) is a rare genetic disease caused by mutations in the TAFAZZIN gene. It is characterized by neutropenia, cardiomyopathy and skeletal myopathy. Neutropenia in BTHS is associated with...
2.
Naveh C, Roberts K, Zakrzewski P, Rice C, Ponce-Garcia F, Fleming K, et al.
J Transl Med
. 2024 Oct;
22(1):899.
PMID: 39367420
No abstract available.
3.
Naveh C, Roberts K, Zakrzewski P, Rice C, Ponce-Garcia F, Fleming K, et al.
J Transl Med
. 2024 Jun;
22(1):526.
PMID: 38822352
Background: Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving...
4.
Millrine D, Rice C, Fernandez J, Jones S
Methods Mol Biol
. 2023 Jun;
2691:81-95.
PMID: 37355539
Antimicrobial host defense is dependent on the rapid recruitment of inflammatory cells to the site of infection, the elimination of invading pathogens, and the efficient resolution of inflammation that minimizes...
5.
Millrine D, Cardus Figueras A, Uceda Fernandez J, Andrews R, Szomolay B, Cossins B, et al.
J Immunol
. 2023 Jun;
211(2):274-286.
PMID: 37272871
Cytokines that signal via STAT1 and STAT3 transcription factors instruct decisions affecting tissue homeostasis, antimicrobial host defense, and inflammation-induced tissue injury. To understand the coordination of these activities, we applied...
6.
Rice C, Lewis P, Ponce-Garcia F, Gibbs W, Groves S, Cela D, et al.
Life Sci Alliance
. 2023 Jan;
6(2).
PMID: 36622345
Neutrophils are vital in defence against pathogens, but excessive neutrophil activity can lead to tissue damage and promote acute respiratory distress syndrome. COVID-19 is associated with systemic expansion of immature...
7.
Cela D, Knackstedt S, Groves S, Rice C, Kwon J, Mordmuller B, et al.
J Leukoc Biol
. 2021 Nov;
111(6):1235-1242.
PMID: 34755385
Peptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role...
8.
Ernst O, Sun J, Lin B, Banoth B, Dorrington M, Liang J, et al.
Sci Signal
. 2021 Aug;
14(694).
PMID: 34344832
Noncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in macrophages is preceded by a Toll-like receptor (TLR)...
9.
Palmieri E, Gonzalez-Cotto M, Baseler W, Davies L, Ghesquiere B, Maio N, et al.
Nat Commun
. 2020 Feb;
11(1):698.
PMID: 32019928
Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine macrophages is responsible...
10.
Rice C, Davies L, Subleski J, Maio N, Gonzalez-Cotto M, Andrews C, et al.
Nat Commun
. 2018 Dec;
9(1):5099.
PMID: 30504842
Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are...