Christopher J Walkey
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Explore the profile of Christopher J Walkey including associated specialties, affiliations and a list of published articles.
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21
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821
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Recent Articles
1.
De Giorgi M, Park S, Castoreno A, Cao M, Hurley A, Saxena L, et al.
Sci Transl Med
. 2025 Feb;
17(785):eadk3920.
PMID: 39937884
Homology-directed repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms...
2.
Walkey C, Snow K, Bulcha J, Cox A, Martinez A, Ljungberg M, et al.
Mol Ther
. 2025 Jan;
33(3):1282-1299.
PMID: 39863928
Gene therapy with adeno-associated virus (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of 10 naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6,...
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Walkey C, Snow K, Bulcha J, Cox A, Martinez A, Ljungberg M, et al.
bioRxiv
. 2024 Sep;
PMID: 39314496
Gene therapy with Adeno-Associated Viral (AAV) vectors requires knowledge of their tropism within the body. Here we analyze the tropism of ten naturally occurring AAV serotypes (AAV3B, AAV4, AAV5, AAV6,...
5.
De Giorgi M, Park S, Castoreno A, Cao M, Hurley A, Saxena L, et al.
bioRxiv
. 2023 Aug;
PMID: 37546995
Homology Directed Repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair...
6.
Huang Q, Chen A, Chan K, Sorensen H, Barry A, Azari B, et al.
PLoS Biol
. 2023 Jul;
21(7):e3002112.
PMID: 37467291
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules. We engineered peptide-modified adeno-associated virus (AAV) capsids that transduce the brain...
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Lorincz R, Alvarez A, Walkey C, Mendonca S, Lu Z, Martinez A, et al.
Biomed Pharmacother
. 2023 Jan;
158:114189.
PMID: 36587560
Biological applications deriving from the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 site-specific nuclease system continue to impact and accelerate gene therapy strategies. Safe and effective in vivo co-delivery of...
9.
Phillips E, Ahmad N, Sun L, Iben J, Walkey C, Rusin A, et al.
Elife
. 2022 May;
11.
PMID: 35611941
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating...
10.
Liang S, Walkey C, Martinez A, Su Q, Dickinson M, Wang D, et al.
Mol Ther
. 2021 Oct;
30(1):238-243.
PMID: 34695545
Genome editing in the lung has the potential to provide long-term expression of therapeutic protein to treat lung genetic diseases. Yet efficient delivery of CRISPR to the lung remains a...