Christopher J Dinsmore
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Explore the profile of Christopher J Dinsmore including associated specialties, affiliations and a list of published articles.
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24
Citations
453
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Recent Articles
11.
Katz J, Jewell J, Guerin D, Lim J, Dinsmore C, Deshmukh S, et al.
J Med Chem
. 2011 May;
54(12):4092-108.
PMID: 21608528
c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an...
12.
Siu T, Kozina E, Jung J, Rosenstein C, Mathur A, Altman M, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7421-5.
PMID: 21044843
This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D....
13.
Beshore D, Liverton N, McIntyre C, Claiborne C, Libby B, Culberson J, et al.
Bioorg Med Chem Lett
. 2010 Mar;
20(8):2493-6.
PMID: 20304642
A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure-activity relationship (SAR) studies described herein...
14.
Peterson S, Stucka S, Dinsmore C
Org Lett
. 2010 Feb;
12(6):1340-3.
PMID: 20175533
A mild and efficient library synthesis technique has been developed for the synthesis of ureas and carbamates from carbamic acids derived from the DBU-catalyzed reaction of amines and gaseous carbon...
15.
Pan B, Chan G, Chenard M, Chi A, Davis L, Deshmukh S, et al.
Cancer Res
. 2010 Feb;
70(4):1524-33.
PMID: 20145145
The receptor tyrosine kinase c-Met is an attractive target for therapeutic blockade in cancer. Here, we describe MK-2461, a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro...
16.
Katz J, Lapointe B, Dinsmore C
J Org Chem
. 2009 Oct;
74(22):8866-9.
PMID: 19845317
A bench-stable potassium trifluoroborate enol ether reagent has been prepared. This reagent is suitable for the incorporation of 2,2-difluoroenolethers into aryl and heteroaryl systems via palladium-mediated cross-coupling with suitable halide...
17.
Regan C, Kiss L, Stump G, McIntyre C, Beshore D, Liverton N, et al.
J Pharmacol Exp Ther
. 2007 Oct;
324(1):322-30.
PMID: 17967939
Drug discovery efforts have focused recently on atrial-selective targets, including the Kv1.5 channel, which underlies the ultrarapid delayed rectifier current, I(Kur), to develop novel treatments for atrial fibrillation (AF). Two...
18.
Trotter B, Nanda K, Kett N, Regan C, Lynch J, Stump G, et al.
J Med Chem
. 2006 Nov;
49(24):6954-7.
PMID: 17125248
Novel 3-cyanoisoquinoline Kv1.5 antagonists have been prepared and evaluated in in vitro and in vivo assays for inhibition of the Kv1.5 potassium channel and its associated cardiac potassium current, IKur....
19.
Nanda K, Nolt M, Cato M, Kane S, Kiss L, Spencer R, et al.
Bioorg Med Chem Lett
. 2006 Sep;
16(22):5897-901.
PMID: 16949818
This letter describes the discovery of a novel series of potent Kv1.5 ion channel antagonists based on a diisopropyl amide scaffold. Structure-activity relationships of functionalized analogs are discussed. Key compound...
20.
Bell I, Stirdivant S, Ahern J, Culberson J, Darke P, Dinsmore C, et al.
Biochemistry
. 2005 Jul;
44(27):9430-40.
PMID: 15996097
The type 1 insulin-like growth factor receptor (IGF-1R) is often overexpressed on tumor cells and is believed to play an important role in anchorage-independent proliferation. Additionally, cell culture studies have...