Sujal V Deshmukh
Overview
Explore the profile of Sujal V Deshmukh including associated specialties, affiliations and a list of published articles.
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24
Citations
219
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Recent Articles
1.
Patel M, Riede J, Bednarczyk D, Poller B, Deshmukh S
Pharm Res
. 2023 Mar;
40(4):937-949.
PMID: 36859748
Purpose: The Extended Clearance Concept Classification System was established as a development-stage tool to provide a framework for identifying fundamental mechanism(s) governing drug disposition in humans. In the present study,...
2.
Ahire D, Patel M, Deshmukh S, Prasad B
Drug Metab Dispos
. 2022 Nov;
51(3):285-292.
PMID: 36446609
Characterization of accurate compositions and total abundance of homologous drug-metabolizing enzymes, such as UDP glucuronosyltransferases (UGTs), is important for predicting the fractional contribution of individual isoforms involved in the metabolism...
3.
Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, et al.
J Med Chem
. 2017 Nov;
60(23):9676-9690.
PMID: 29156136
The discovery of a potent selective low dose Janus kinase 1 (JAK1) inhibitor suitable for clinical evaluation is described. As part of an overall goal to minimize dose, we pursued...
4.
Elwood F, Witter D, Piesvaux J, Kraybill B, Bays N, Alpert C, et al.
J Pharmacol Exp Ther
. 2017 Feb;
361(2):229-244.
PMID: 28193636
Reversible janus associated kinase (JAK) inhibitors such as tofacitinib and decernotinib block cytokine signaling and are efficacious in treating autoimmune diseases. However, therapeutic doses are limited due to inhibition of...
5.
Martin I, Hill S, Baker J, Deshmukh S, Mulrooney E
Drug Metab Dispos
. 2016 Jun;
44(8):1435-40.
PMID: 27260151
A preclinical drug candidate, MRK-1 (Merck candidate drug parent compound), was found to elicit tumor regression in a mouse xenograft model. Analysis of samples from these studies revealed significant levels...
6.
Simov V, Deshmukh S, Dinsmore C, Elwood F, Fernandez R, Garcia Y, et al.
Bioorg Med Chem Lett
. 2016 Mar;
26(7):1803-8.
PMID: 26927423
The mammalian Janus Kinases (JAK1, JAK2, JAK3 and TYK2) are intracellular, non-receptor tyrosine kinases whose activities have been associated in the literature and the clinic with a variety of hyperproliferative...
7.
Fischer C, Zultanski S, Zhou H, Methot J, Shah S, Hayashi I, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3488-94.
PMID: 26212776
Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42...
8.
Methot J, Fischer C, Li C, Rivkin A, Ahearn S, Brown W, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3495-500.
PMID: 26142947
The triazolyl amide γ-secretase modulators are potent alternatives to the cinnamyl amides that have entered the clinic for the treatment of Alzheimer's disease. Herein we build on the lead benzoazepinones...
9.
Burke R, Somasuntharam I, Rearden P, Brown D, Deshmukh S, DiPietro M, et al.
Pharm Res
. 2014 Jul;
31(12):3445-60.
PMID: 24980206
Purpose: To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo,...
10.
Northrup A, Katcher M, Altman M, Chenard M, Daniels M, Deshmukh S, et al.
J Med Chem
. 2013 Feb;
56(6):2294-310.
PMID: 23379595
This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigation...