Christopher Douville
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Explore the profile of Christopher Douville including associated specialties, affiliations and a list of published articles.
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37
Citations
2925
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Recent Articles
1.
Pearlman A, Wang Y, Kalluri A, Parker M, Cohen J, Dudley J, et al.
medRxiv
. 2024 Dec;
PMID: 39677487
Statement Of Significance: There is a paucity of technologies beyond surgical biopsy that can accurately diagnose central nervous system neoplasms. We developed a novel, sensitive and highly specific assay that...
2.
Chien Y, Wang Y, Huang P, Lawson B, Kolin D, Chui M, et al.
Am J Surg Pathol
. 2024 Feb;
48(4):475-486.
PMID: 38298022
Serous tubal intraepithelial carcinoma (STIC) is the fallopian tube precursor lesion for most cases of pelvic high-grade serous carcinoma (HGSC). To date, the morphologic, molecular, and clinical heterogeneity of STIC...
3.
Douville C, Lahouel K, Kuo A, Grant H, Avigdor B, Curtis S, et al.
Sci Transl Med
. 2024 Jan;
16(731):eadi3883.
PMID: 38266106
We previously described an approach called RealSeqS to evaluate aneuploidy in plasma cell-free DNA through the amplification of ~350,000 repeated elements with a single primer. We hypothesized that an unbiased...
4.
Wang Y, Douville C, Chien Y, Wang B, Chen C, Pinto A, et al.
Clin Cancer Res
. 2023 Dec;
30(3):600-615.
PMID: 38048050
Purpose: Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous carcinoma (HGSC). Other potential tubal lesions include p53 signatures and tubal intraepithelial lesions....
5.
Mattox A, Douville C, Wang Y, Popoli M, Ptak J, Silliman N, et al.
Cancer Discov
. 2023 Aug;
13(10):2166-2179.
PMID: 37565753
Significance: The origin of excess cfDNA in patients with cancer is unknown. Using cfDNA methylation patterns, we determined that neither the tumor nor the surrounding normal tissue contributes this excess...
6.
Douville C, Curtis S, Summers M, Azad T, Rincon-Torroella J, Wang Y, et al.
Cell Rep Med
. 2023 Aug;
4(8):101148.
PMID: 37552989
It is often challenging to distinguish cancerous from non-cancerous lesions in the brain using conventional diagnostic approaches. We introduce an analytic technique called Real-CSF (repetitive element aneuploidy sequencing in CSF)...
7.
Wang Y, Douville C, Cohen J, Mattox A, Curtis S, Silliman N, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(15):e2220704120.
PMID: 37014860
The analysis of cell-free DNA (cfDNA) from plasma offers great promise for the earlier detection of cancer. At present, changes in DNA sequence, methylation, or copy number are the most...
8.
Mattox A, Douville C, Silliman N, Ptak J, Dobbyn L, Schaefer J, et al.
Elife
. 2022 Mar;
11.
PMID: 35244537
Malignant peripheral nerve sheath tumors (MPNST) are the deadliest cancer that arises in individuals diagnosed with neurofibromatosis and account for nearly 5% of the 15,000 soft tissue sarcomas diagnosed in...
9.
Bridgeford E, Wang S, Wang Z, Xu T, Craddock C, Dey J, et al.
PLoS Comput Biol
. 2021 Sep;
17(9):e1009279.
PMID: 34529652
Replicability, the ability to replicate scientific findings, is a prerequisite for scientific discovery and clinical utility. Troublingly, we are in the midst of a replicability crisis. A key to replicability...
10.
Naidoo J, Schreck K, Fu W, Hu C, Carvajal-Gonzalez A, Connolly R, et al.
J Immunother Cancer
. 2021 Aug;
9(8).
PMID: 34380662
Background: The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown. Methods: We undertook a phase II trial of pembrolizumab in patients with LMM from...