Allan D Capili
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Explore the profile of Allan D Capili including associated specialties, affiliations and a list of published articles.
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13
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577
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Recent Articles
1.
Martin C, Datta A, Littlefield C, Kalra A, Chapron C, Wawersik S, et al.
Sci Transl Med
. 2020 Mar;
12(536).
PMID: 32213632
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical...
2.
Dagbay K, Treece E, Frederick C Streich Jr , Jackson J, Faucette R, Nikiforov A, et al.
J Biol Chem
. 2020 Feb;
295(16):5404-5418.
PMID: 32075906
Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in...
3.
Sule S, Fernandez J, Mecozzi V, Kravets Y, Yang W, Feng P, et al.
J Pharm Sci
. 2017 Sep;
106(12):3507-3514.
PMID: 28860086
Characterizing molecular charge variants or isoforms is essential for understanding safety, potency, and bioavailability of antibody therapeutics. However, there is little information on how they influence stability and viscosity-properties governing...
4.
Day E, Capili A, Borysenko C, Zafari M, Whitty A
Anal Biochem
. 2013 May;
440(1):96-107.
PMID: 23711722
We describe a general Biacore method for measuring equilibrium binding affinities and stoichiometries for interactions between unmodified proteins and their unmodified ligands free in solution. Mixtures of protein and ligand...
5.
Vendel M, Favis M, Snyder W, Huang F, Capili A, Dong J, et al.
Arch Biochem Biophys
. 2012 Jan;
526(2):188-93.
PMID: 22230329
Escherichia coli (E. coli) is the most commonly used organism for expressing antibody fragments such as single chain antibody Fvs (scFvs). Previously, we have utilized E. coli to express well-folded...
6.
Olsen S, Capili A, Lu X, Tan D, Lima C
Nature
. 2010 Feb;
463(7283):906-12.
PMID: 20164921
E1 enzymes activate ubiquitin (Ub) and ubiquitin-like (Ubl) proteins in two steps by carboxy-terminal adenylation and thioester bond formation to a conserved catalytic cysteine in the E1 Cys domain. The...
7.
Lu X, Olsen S, Capili A, Cisar J, Lima C, Tan D
J Am Chem Soc
. 2010 Jan;
132(6):1748-9.
PMID: 20099854
Semisynthetic, mechanism-based protein inhibitors of ubiquitin (Ub) and ubiquitin-like modifier (Ubl) activating enzymes (E1s) have been developed to target E1-catalyzed adenylation and thioesterification of the Ub/Ubl C-terminus during the processes...
8.
Mohideen F, Capili A, Bilimoria P, Yamada T, Bonni A, Lima C
Nat Struct Mol Biol
. 2009 Aug;
16(9):945-52.
PMID: 19684601
Phosphorylation and small ubiquitin-like modifier (SUMO) conjugation contribute to the spatial and temporal regulation of substrates containing phosphorylation-dependent SUMO consensus motifs (PDSMs). Myocyte-enhancement factor 2 (MEF2) is a transcription factor...
9.
Capili A, Lima C
Curr Opin Struct Biol
. 2007 Oct;
17(6):726-35.
PMID: 17919899
Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced...
10.
Peng H, Gibson L, Capili A, Borden K, Osborne M, Harper S, et al.
J Mol Biol
. 2007 May;
370(2):269-89.
PMID: 17512541
The KRAB domain is a 75 amino acid transcriptional repression module that is encoded by more than 400 zinc finger protein genes, making it the most abundant repression domain in...