Christopher Cavanaugh
Overview
Explore the profile of Christopher Cavanaugh including associated specialties, affiliations and a list of published articles.
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19
Citations
899
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0
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Recent Articles
1.
Fleming J, McCloskey M, Gray K, Nash D, Leung V, Michas C, et al.
Curr Res Toxicol
. 2025 Feb;
8:100218.
PMID: 39944108
Animal models of the neuromuscular junction (NMJ) have been widely studied but exhibit critical differences from human biology limiting utility in drug and disease modelling. Challenges with scarcity, scalability, throughput,...
2.
Cavanaugh C, Hesson J, Mathieu J
Methods Mol Biol
. 2023 Dec;
2735:129-143.
PMID: 38038847
Recent advances in patient-derived induced Pluripotent Stem Cell (iPSC) generation, improvement of cardiomyocyte-directed differentiation protocols, and the availability of new genome editing techniques have opened up new avenues for disease...
3.
Ware C, Jonlin E, Anderson D, Cavanaugh C, Hesson J, Sidhu S, et al.
Stem Cell Rev Rep
. 2023 Sep;
19(8):2980-2990.
PMID: 37702917
Embryonic development is a continuum in vivo. Transcriptional analysis can separate established human embryonic stem cells (hESC) into at least four distinct developmental pluripotent stages, two naïve and two primed,...
4.
Hussein A, Wang Y, Mathieu J, Margaretha L, Song C, Jones D, et al.
Dev Cell
. 2020 Jan;
52(2):236-250.e7.
PMID: 31991105
Regulation of embryonic diapause, dormancy that interrupts the tight connection between developmental stage and time, is still poorly understood. Here, we characterize the transcriptional and metabolite profiles of mouse diapause...
5.
Alam M, Cavanaugh C, Pereira M, Babu U, Williams K
Int J Med Microbiol
. 2020 Jan;
310(2):151397.
PMID: 31974050
Foodborne Listeria monocytogenes (Lm) causes serious illness and death in immunosuppressed hosts, including the elderly population. We investigated Lm susceptibility and inflammatory cytokines in geriatric mice. Young-adult and old mice...
6.
Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, et al.
Cell Cycle
. 2018 Feb;
17(5):535-549.
PMID: 29466914
To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The...
7.
Ma W, Ay F, Lee C, Gulsoy G, Deng X, Cook S, et al.
Methods
. 2018 Feb;
142:59-73.
PMID: 29382556
The folding and three-dimensional (3D) organization of chromatin in the nucleus critically impacts genome function. The past decade has witnessed rapid advances in genomic tools for delineating 3D genome architecture....
8.
Costales M, Alam M, Cavanaugh C, Williams K
Nitric Oxide
. 2017 Nov;
72:7-15.
PMID: 29108754
Surface enzymes CD39 (nucleoside triphosphate dephosphorylase) and CD73 (ecto-5'-nucleotidase) mediate the synthesis of extracellular adenosine that can regulate immune responses. Adenosine produced by CD39/CD73 acts via adenosine receptors (ARs). CD73...
9.
Tasmin R, Hasan N, Grim C, Grant A, Choi S, Alam M, et al.
PLoS One
. 2017 May;
12(5):e0176938.
PMID: 28481935
Salmonella Typhimurium is the leading cause of human non-typhoidal gastroenteritis in the US. S. Kentucky is one the most commonly recovered serovars from commercially processed poultry carcasses. This study compared...
10.
Bargaje R, Trachana K, Shelton M, McGinnis C, Zhou J, Chadick C, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(9):2271-2276.
PMID: 28167799
Steering the differentiation of induced pluripotent stem cells (iPSCs) toward specific cell types is crucial for patient-specific disease modeling and drug testing. This effort requires the capacity to predict and...