Christopher C Presley
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Explore the profile of Christopher C Presley including associated specialties, affiliations and a list of published articles.
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9
Citations
31
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Recent Articles
1.
Engers J, Bollinger K, Capstick R, Long M, Bender A, Dickerson J, et al.
ACS Chem Neurosci
. 2024 Aug;
15(18):3421-3433.
PMID: 39197083
Herein we report progress toward a backup clinical candidate to the M positive allosteric modulator (PAM) VU319/ACP-319. Scaffold-hopping from the pyrrolo[2,3-]pyridine-based M PAM VU6007477 to isomeric pyrrolo[3,2-]pyridine and thieno[3,2-]pyridine congeners...
2.
Li J, Orsi D, Engers J, Long M, Capstick R, Maurer M, et al.
J Med Chem
. 2024 Aug;
67(16):14394-14413.
PMID: 39105778
While the muscarinic acetylcholine receptor mAChR subtype 5 (M) has been studied over decades, recent findings suggest that more in-depth research is required to elucidate a thorough understanding of its...
3.
Abe M, Coleman J, Presley C, Schley N, Lindsley C
J Org Chem
. 2024 Feb;
89(5):3500-3508.
PMID: 38340064
Sp-enriched small molecules play a critical role in developing drug candidates. While designing analogues with greater sp character, a methodology utilizing a less explored cyclic-aziridine amide ring-opening reaction to generate...
4.
Bender A, Carter T, Spock M, Rodriguez A, Dickerson J, Rook J, et al.
Bioorg Med Chem Lett
. 2021 Nov;
56:128479.
PMID: 34838649
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR). Chiral separation and...
5.
Presley C, Perry C, Childress E, Mulder M, Luscombe V, Rodriguez A, et al.
ACS Omega
. 2019 Aug;
4(7):12782-12789.
PMID: 31460402
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom...
6.
Presley C, Lindsley C
ACS Chem Neurosci
. 2018 Sep;
9(10):2503-2518.
PMID: 30247870
Opium is the latex from the opium poppy Papaver somniferum L., which humankind has utilized since ancient Mesopotamia all the way to modern times. Opium used to be surrounded in...
7.
Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium
Presley C, Du Y, Dalal S, Merino E, Butler J, Rakotonandrasana S, et al.
Bioorg Med Chem
. 2017 Jun;
25(15):4203-4211.
PMID: 28648491
Antiplasmodial bioassay guided fractionation of a Madagascar collection of Crinum firmifolium led to the isolation of seven compounds. Five of the seven compounds were determined to be 2-alkylquinolin-4(1H)-ones with varying...
8.
Presley C, Krai P, Dalal S, Su Q, Cassera M, Goetz M, et al.
Bioorg Med Chem
. 2016 Sep;
24(21):5418-5422.
PMID: 27624525
Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2 were determined from their spectroscopic data...
9.
Presley C, Rakotondraibe L, Brodie P, Callmander M, Randrianaivo R, Rasamison V, et al.
Nat Prod Commun
. 2015 Oct;
10(9):1505-7.
PMID: 26435765
Antiproliferative bioassay-guided fractionation of the ethanolic extract of the endemic Madagascan plant Metaporana sericosepala led to the first natural product isolation of a butenolide diterpene, which was synthesized during an...