A Synthetic Butenolide Diterpene is Now a Natural Product Isolated from Metaporana Sericosepala, a Plant from the Madagascar Dry Forest

Overview

Journal Nat Prod Commun

Publisher Sage Publications

Date 2015 Oct 6

PMID 26435765

Citations 2

Authors

Christopher C Presley

L Harinantenaina Rakotondraibe

Peggy J Brodie

Martin W Callmander

Richard Randrianaivo

Vincent E Rasamison

Etienne Rakotobe

David G I Kingston

Affiliations

Soon will be listed here.

Abstract

Antiproliferative bioassay-guided fractionation of the ethanolic extract of the endemic Madagascan plant Metaporana sericosepala led to the first natural product isolation of a butenolide diterpene, which was synthesized during an anti-inflammatory study in 1988. The structure of the compound was elucidated as 3-homofarnesyl-4-hydroxybutenolide (1) by analysis of its spectroscopic data, including 1D- and 2D-NMR data and chemical evidence. The once synthetic compound can now also be considered as a natural product. Compound 1 had modest antiproliferative activity towards the A2780 ovarian cancer cell line,with an IC50 value of 8 µM.

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