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Christina Signoretti

Explore the profile of Christina Signoretti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 15
Followers 0
Related Specialties
Biochemistry
General Medicine
Neurology
Top 10 Co-Authors
Sachin A Gupte
Samuel Fatehi
Victor Garcia
Angelo DAlessandro
Shun Matsumura
Libor Velisek
Gun-Hoo Park
Carla Hu
Rajamma Mathew
Joy S Park
Published In
J Biol Chem
Int J Mol Sci
Neuron
PLoS One
bioRxiv
Affiliations
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Recent Articles
1.
Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease
Signoretti C, Matsumura S, Fatehi S, DSilva M, Mathew R, Cendali F, et al.
J Am Heart Assoc . 2024 Sep; 13(19):e035174. PMID: 39291493
Background: G6PD (glucose-6-phosphate-dehydrogenase) is a key enzyme in the glycolytic pathway and has been implicated in the pathogenesis of cancer and pulmonary hypertension-associated vascular remodeling. Here, we investigated the role...
2.
Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats
Matsumura S, Signoretti C, Fatehi S, Tumenbayar B, DAddario C, Nimmer E, et al.
J Biol Chem . 2024 Jun; 300(7):107460. PMID: 38876306
Obesity is a major risk factor for liver and cardiovascular diseases. However, obesity-driven mechanisms that contribute to the pathogenesis of multiple organ diseases are still obscure and treatment is inadequate....
3.
Development of a Python-based electron ionization mass spectrometry amino acid and peptide fragment prediction model
McBrayer D, Signoretti C, Pesce M, Flood B, Varghese S, Sirdah F, et al.
PLoS One . 2024 Feb; 19(2):e0297752. PMID: 38363755
The increased fragmentation caused by harsher ionization methods used during mass spectrometry such as electron ionization can make interpreting the mass spectra of peptides difficult. Therefore, the development of tools...
4.
G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall
Signoretti C, Gupte S
Int J Mol Sci . 2023 Dec; 24(23). PMID: 38069050
Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and the de novo silencing of genes genome-wide,...
5.
Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall
Signoretti C, Gupte S
bioRxiv . 2023 Mar; PMID: 36945640
Background: Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of genetic imprinting and silencing of genes genome-wide, is known...
6.
Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
Zhu Q, Mishra A, Park J, Liu D, Le D, Gonzalez S, et al.
Neuron . 2023 Jan; 111(6):807-823.e7. PMID: 36626901
Previously, we demonstrated the efficacy of human pluripotent stem cell (hPSC)-derived GABAergic cortical interneuron (cIN) grafts in ameliorating seizures. However, a safe and reliable clinical translation requires a mechanistic understanding...
7.
Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension
Jacob C, Kitagawa A, Signoretti C, Dzieciatkowska M, DAlessandro A, Gupte A, et al.
J Biol Chem . 2022 Nov; 298(12):102691. PMID: 36372233
DNA methylation potentially contributes to the pathogenesis of pulmonary hypertension (PH). However, the role of DNA methyltransferases (DNMTs: 1, 3a, and 3b), the epigenetic writers, in modulating DNA methylation observed...