Libor Velisek
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Explore the profile of Libor Velisek including associated specialties, affiliations and a list of published articles.
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78
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1232
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Recent Articles
1.
Obot P, Cibelli A, Pan J, Velisek L, Veliskova J, Scemes E
ASN Neuro
. 2024 Jul;
16(1):2371164.
PMID: 39024558
There is a high co-morbidity between childhood epilepsy and autism spectrum disorder (ASD), with age of seizure onset being a critical determinant of behavioral outcomes. The interplay between these comorbidities...
2.
Chachua T, Chern C, Veliskova J, Velisek L
Neurosci Lett
. 2023 Aug;
813:137431.
PMID: 37591361
Epileptic spasms during infancy represent a devastating and refractory epilepsy syndrome. To advance studies on mechanisms and treatment using available mouse mutant models, we transferred our validated rat model of...
3.
Obot P, Subah G, Schonwald A, Pan J, Velisek L, Veliskova J, et al.
ASN Neuro
. 2023 Jun;
15:17590914231184712.
PMID: 37365910
Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate). In the nervous system, activation of Panx1...
4.
Obot P, Subah G, Schonwald A, Pan J, Velisek L, Veliskova J, et al.
bioRxiv
. 2023 Jan;
PMID: 36711845
Pannexin 1 (Panx1) are ubiquitously expressed proteins that form plasma membrane channels permeable to anions and moderate sized signaling molecules (e.g., ATP, glutamate). In the nervous system, activation of Panx1...
5.
Zhu Q, Mishra A, Park J, Liu D, Le D, Gonzalez S, et al.
Neuron
. 2023 Jan;
111(6):807-823.e7.
PMID: 36626901
Previously, we demonstrated the efficacy of human pluripotent stem cell (hPSC)-derived GABAergic cortical interneuron (cIN) grafts in ameliorating seizures. However, a safe and reliable clinical translation requires a mechanistic understanding...
6.
Chern C, Laukova M, Schonwald A, Kudova E, Chodounska H, Chern C, et al.
Pharmacol Rep
. 2022 Nov;
75(1):177-188.
PMID: 36422805
Background: Neurosteroids are investigated as effective antidotes for the poisoning induced by tetramethylenedisulfotetramine (TMDT) as well as treatments for epileptic spasms during infancy. Both these conditions are quite resistant to...
7.
Veliskova J, Marra C, Liu Y, Shekhar A, Park D, Iatckova V, et al.
Epilepsia
. 2021 May;
62(7):1546-1558.
PMID: 33982289
Objective: Fibroblast growth factor homologous factors (FHFs) are brain and cardiac sodium channel-binding proteins that modulate channel density and inactivation gating. A recurrent de novo gain-of-function missense mutation in the...
8.
Obot P, Velisek L, Veliskova J, Scemes E
ASN Neuro
. 2021 Apr;
13:17590914211007273.
PMID: 33910381
Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes...
9.
Velisek L, Veliskova J
Pharmacol Ther
. 2020 May;
212:107578.
PMID: 32417271
Infantile spasms (IS or epileptic spasms during infancy) were first described by Dr. William James West (aka West syndrome) in his own son in 1841. While rare by definition (occurring...
10.
McCarthy E, Shakil F, Saint Ange P, Morris Cameron E, Miller J, Pathak S, et al.
Epilepsia
. 2020 Apr;
61(5):892-902.
PMID: 32301507
Objective: BRD2 is a human gene repeatedly linked to and associated with juvenile myoclonic epilepsy (JME). Here, we define the developmental stage when increased seizure susceptibility first manifests in heterozygous...