Christian Le Gouill
Overview
Explore the profile of Christian Le Gouill including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
42
Citations
861
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Wright S, Avet C, Gaitonde S, Muneta-Arrate I, Le Gouill C, Hogue M, et al.
Sci Signal
. 2024 Jun;
17(841):eadi4747.
PMID: 38889226
G protein-coupled receptors (GPCRs) regulate cellular signaling processes by coupling to diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits. Biosensors based on bioluminescence resonance energy...
2.
Gross F, Mancini A, Breton B, Kobayashi H, Pereira P, Le Gouill C, et al.
Commun Biol
. 2024 Mar;
7(1):250.
PMID: 38429428
Mutations of receptor tyrosine kinases (RTKs) are associated with the development of many cancers by modifying receptor signaling and contributing to drug resistance in clinical settings. We present enhanced bystander...
3.
Wright S, Motso A, Koutsilieri S, Beusch C, Sabatier P, Berghella A, et al.
Nat Commun
. 2023 Oct;
14(1):6243.
PMID: 37813859
G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step...
4.
Plouffe B, Karamitri A, Flock T, Gallion J, Houston S, Daly C, et al.
ACS Pharmacol Transl Sci
. 2022 Jul;
5(2):89-101.
PMID: 35846981
G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting...
5.
Heydenreich F, Plouffe B, Rizk A, Milic D, Zhou J, Breton B, et al.
Mol Pharmacol
. 2022 Jul;
102(3):139-149.
PMID: 35779859
Activation of G protein-coupled receptors by agonists may result in the activation of one or more G proteins and recruitment of arrestins. The extent of the activation of each of...
6.
Avet C, Mancini A, Breton B, Le Gouill C, Hauser A, Normand C, et al.
Elife
. 2022 Mar;
11.
PMID: 35302493
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins...
7.
Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, et al.
ACS Pharmacol Transl Sci
. 2021 Oct;
4(5):1614-1627.
PMID: 34661078
Melatonin is a hormone mainly produced by the pineal gland and MT is one of the two G protein-coupled receptors (GPCRs) mediating its action. Despite an increasing number of available...
8.
Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, et al.
ACS Pharmacol Transl Sci
. 2021 Oct;
4(5):1483-1498.
PMID: 34661070
Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon contributes...
9.
Ehrlich A, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, et al.
Mol Brain
. 2021 Sep;
14(1):151.
PMID: 34583741
The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for cancer...
10.
Wright S, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, et al.
Proc Natl Acad Sci U S A
. 2021 May;
118(20).
PMID: 33990469
G protein-coupled receptors (GPCRs) are gatekeepers of cellular homeostasis and the targets of a large proportion of drugs. In addition to their signaling activity at the plasma membrane, it has...