Christian Le Gouill
Overview
Explore the profile of Christian Le Gouill including associated specialties, affiliations and a list of published articles.
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42
Citations
861
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Recent Articles
11.
Leguay K, Decelle B, He Y, Pagniez A, Hogue M, Kobayashi H, et al.
J Cell Sci
. 2021 Mar;
134(7).
PMID: 33712451
Ezrin, radixin and moesin compose the family of ERM proteins. They link actin filaments and microtubules to the plasma membrane to control signaling and cell morphogenesis. Importantly, their activity promotes...
12.
Avet C, Sturino C, Grastilleur S, Le Gouill C, Semache M, Gross F, et al.
Commun Biol
. 2020 Nov;
3(1):719.
PMID: 33247181
Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and pain, therefore representing a promising therapeutic target for the treatment of immune-mediated inflammatory diseases. However, as for other GPCRs, PAR2 can...
13.
Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin R, Longpre J, et al.
Sci Rep
. 2020 May;
10(1):8779.
PMID: 32471984
A comprehensive understanding of signalling downstream of GPCRs requires a broad approach to capture novel signalling modalities in addition to established pathways. Here, using an array of sixteen validated BRET-based...
14.
Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, et al.
Nat Commun
. 2020 Apr;
11(1):1929.
PMID: 32300106
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
15.
Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, et al.
Nat Commun
. 2019 Sep;
10(1):4075.
PMID: 31501422
Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors should be specifically activated or...
16.
Bolognini D, Barki N, Butcher A, Hudson B, Sergeev E, Molloy C, et al.
Nat Chem Biol
. 2019 Apr;
15(5):489-498.
PMID: 30992568
Differentiating actions of short chain fatty acids (SCFAs) at free fatty acid receptor 2 (FFA2) from other free fatty acid-responsive receptors and from non-receptor-mediated effects has been challenging. Using a...
17.
Ehrlich A, Semache M, Gross F, Da Fonte D, Runtz L, Colley C, et al.
iScience
. 2019 Mar;
14:47-57.
PMID: 30925410
G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals. The concept of ligand-dependent biased signaling raises the possibility of developing drugs with improved efficacy and safety profiles,...
18.
Wright S, Canizal M, Benkel T, Simon K, Le Gouill C, Matricon P, et al.
Sci Signal
. 2018 Dec;
11(559).
PMID: 30514810
Frizzleds (FZDs) are a group of seven transmembrane-spanning (7TM) receptors that belong to class F of the G protein-coupled receptor (GPCR) superfamily. FZDs bind WNT proteins to stimulate diverse signaling...
19.
Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume J, et al.
Sci Signal
. 2018 Aug;
11(545).
PMID: 30154102
Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in , which encodes the melatonin receptor MT, a G protein-coupled receptor (GPCR), are associated with...
20.
Schonegge A, Gallion J, Picard L, Wilkins A, Le Gouill C, Audet M, et al.
Nat Commun
. 2017 Dec;
8(1):2169.
PMID: 29255305
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in...