Chew L Lau
Overview
Explore the profile of Chew L Lau including associated specialties, affiliations and a list of published articles.
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17
Citations
222
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Recent Articles
1.
McLeod V, Chiam M, Perera N, Lau C, Boon W, Turner B
Front Endocrinol (Lausanne)
. 2022 Mar;
13:808479.
PMID: 35273564
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling the androgen receptor (AR), predominate in males, and have widespread actions...
2.
McLeod V, Cuic B, Chiam M, Lau C, Turner B
Genesis
. 2020 Aug;
58(10-11):e23390.
PMID: 32744751
The Cre-loxP strategy for tissue selective gene deletion has become a widely employed tool in neuroscience research. The validity of these models is largely underpinned by the temporal and spatial...
3.
McLeod V, Chiam M, Lau C, Rupasinghe T, Boon W, Turner B
Endocrinology
. 2020 Jul;
161(9).
PMID: 32621747
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons which shows sexual dimorphism in its incidence, age of onset, and progression rate. All steroid hormones, including androgens, estrogens,...
4.
Barton S, Lau C, Chiam M, Tomas D, Muyderman H, Beart P, et al.
Neurochem Res
. 2020 May;
45(6):1451-1459.
PMID: 32410044
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase 1 (SOD1) is partly non-cell autonomous, involving cellular dysfunction of astrocytes. Whether non-cell autonomous effects occur...
5.
Maclean F, Lau C, Ozergun S, OShea R, Cederfur C, Wang J, et al.
J Mater Chem B
. 2020 Apr;
5(22):4073-4083.
PMID: 32264140
Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibits functional repair and recovery if persistent. Many biomaterial systems have been...
6.
McLeod V, Lau C, Chiam M, Rupasinghe T, Roessner U, Djouma E, et al.
Br J Pharmacol
. 2019 Mar;
176(13):2111-2130.
PMID: 30849180
Background And Purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are...
7.
Shin Y, Ryall J, Britto J, Lau C, Devenish R, Nagley P, et al.
J Neurochem
. 2019 Jan;
149(2):269-283.
PMID: 30664245
Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuronal mitophagy by disruption of mitochondrial energy metabolism in primary neurons. Mitophagy was examined in...
8.
Perera N, Sheean R, Lau C, Shin Y, Beart P, Horne M, et al.
Autophagy
. 2017 Oct;
14(3):534-551.
PMID: 28980850
Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent...
9.
Wallis N, Lau C, Farg M, Atkin J, Beart P, OShea R
Neurochem Res
. 2017 Sep;
43(1):166-179.
PMID: 28861673
Astrocytes contribute to the death of motor neurons via non-cell autonomous mechanisms of injury in amyotrophic lateral sclerosis (ALS). Since mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) underlie...
10.
Mercer L, Higgins G, Lau C, Lawrence A, Beart P
Neurochem Int
. 2017 Jan;
105:80-90.
PMID: 28122248
Toxicity of 3,4-methylenedioxymethamphetamine (MDMA) towards biogenic amine neurons is well documented and in primate brain predominantly affects serotonin (5-HT) neurons. MDMA induces damage of 5-HT axons and nerve fibres and...