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» Authors » Chew L Lau

Chew L Lau

Explore the profile of Chew L Lau including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 222
Followers 0
Related Specialties
Neurology
Chemistry
Cell Biology
Top 10 Co-Authors
Philip M Beart
Ross D OShea
Bradley J Turner
Mathew D F Chiam
Malcolm K Horne
Victoria M McLeod
David R Nisbet
Francesca L Maclean
Yea Seul Shin
Holly S Cate
Published In
Neurochem Res
J Neurochem
Neurochem Int
Neurotox Res
Autophagy
Affiliations
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Recent Articles
11.
Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis
OShea R, Lau C, Zulaziz N, Maclean F, Nisbet D, Horne M, et al.
Front Neurosci . 2015 Mar; 9:50. PMID: 25750613
Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK)...
12.
3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes
Lau C, Kovacevic M, Tingleff T, Forsythe J, Cate H, Merlo D, et al.
J Neurochem . 2014 Mar; 130(2):215-26. PMID: 24588462
Astrocytes are a target for regenerative neurobiology because in brain injury their phenotype arbitrates brain integrity, neuronal death and subsequent repair and reconstruction. We explored the ability of 3D scaffolds...
13.
Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses
Lau C, Perreau V, Chen M, Cate H, Merlo D, Cheung N, et al.
J Cell Physiol . 2011 May; 227(3):1199-211. PMID: 21604263
Inhibitors of Rho kinase (ROCK) have potential for management of neurological disorders by inhibition of glial scarring. Since astrocytes play key roles in brain physiology and pathology, we determined changes...
14.
Transportable and non-transportable inhibitors of L-glutamate uptake produce astrocytic stellation and increase EAAT2 cell surface expression
Lau C, Beart P, OShea R
Neurochem Res . 2010 Feb; 35(5):735-42. PMID: 20143158
Astrocytic excitatory amino acid transporters (EAATs) regulate excitatory transmission and limit excitotoxicity. Evidence for a functional interface between EAATs and glial fibrillary acidic protein (GFAP) relevant to astrocytic morphology led...
15.
GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death
Diwakarla S, Mercer L, Kardashsyan L, Chu P, Shin Y, Lau C, et al.
J Neurochem . 2009 Apr; 109 Suppl 1:198-206. PMID: 19393028
GABAergic striatal neurons are compromised in basal ganglia pathologies and we analysed how insult nature determined their patterns of injury and recruitment of the intrinsic mitochondrial pathway during programmed cell...
16.
Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1
OShea R, Lau C, Farso M, Diwakarla S, Zagami C, Svendsen B, et al.
Neurochem Int . 2006 Mar; 48(6-7):604-10. PMID: 16530295
Excitatory amino acid transporters (EAATs) are responsible for homeostasis of extracellular L-glutamate, and the glial transporters are functionally dominant. EAAT expression or function is altered in acute and chronic neurological...
17.
Regulation of glutamate transporters in astrocytes: evidence for a relationship between transporter expression and astrocytic phenotype
Zagami C, OShea R, Lau C, Cheema S, Beart P
Neurotox Res . 2005 Jan; 7(1-2):143-9. PMID: 15639805
The astrocytic glutamate transporters, EAAT1 and EAAT2, remove released L-glutamate from the synaptic milieu thereby maintaining normal excitatory transmission. EAAT dysfunction during the excitotoxicity and oxidative stress of neurological insults...