Bradley J Turner
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Explore the profile of Bradley J Turner including associated specialties, affiliations and a list of published articles.
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85
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3988
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Recent Articles
1.
Amin A, Perera N, Tomas D, Cuic B, Radwan M, Hatters D, et al.
Int J Pharm
. 2024 May;
659:124198.
PMID: 38816263
Autophagy, an intracellular degradation system, plays a vital role in protecting cells by clearing damaged organelles, pathogens, and protein aggregates. Autophagy upregulation through pharmacological interventions has gained significant attention as...
2.
Yeoh Y, Amin A, Cuic B, Tomas D, Turner B, Shabanpoor F
Biomed Pharmacother
. 2024 May;
175:116737.
PMID: 38749176
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS) disorders by modulating gene expression with high selectivity and specificity. However, the poor permeability...
3.
Liu X, Xin D, Zhong X, Zhao C, Li Z, Zhang L, et al.
Cell
. 2024 May;
187(10):2465-2484.e22.
PMID: 38701782
Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found...
4.
Koehn L, Steele J, Schittenhelm R, Turner B, Nicolazzo J
Mol Pharm
. 2024 Feb;
21(4):1756-1767.
PMID: 38415587
Amyotrophic lateral sclerosis (ALS) is characterized by death and dysfunction of motor neurons that result in a rapidly progressing loss of motor function. While there are some data on alterations...
5.
Afiat B, Zhao D, Wong V, Perera N, Turner B, Nguyen C, et al.
Neurobiol Aging
. 2023 Aug;
131:74-87.
PMID: 37586253
This study quantified age-related changes to retinal autophagy using the CAG-RFP-EGFP-LC3 autophagy reporter mice and considered how aging impacts autophagic responses to acute intraocular pressure (IOP) stress. IOP was elevated...
6.
Pan Y, Kagawa Y, Sun J, Turner B, Huang C, Shah A, et al.
Pharmaceutics
. 2022 Dec;
14(12).
PMID: 36559296
For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood-brain barrier (BBB). As mounting evidence suggests that the...
7.
Avila L, Leiva S, Abascal-Ponciano G, Flees J, Sweeney K, Wilson J, et al.
J Anim Sci
. 2022 Jul;
100(8).
PMID: 35908786
Skeletal muscle growth is largely dependent on the proliferation and differentiation of muscle-specific stem cells known as satellite cells (SC). Previous work has shown that dietary inclusion of the vitamin...
8.
De Silva S, Turner B, Perera N
Metabolites
. 2022 Jul;
12(7).
PMID: 35888698
Amyotrophic lateral sclerosis (ALS) patients show a myriad of energetic abnormalities, such as weight loss, hypermetabolism, and dyslipidaemia. Evidence suggests that these indices correlate with and ultimately affect the duration...
9.
Sadler G, Lewis K, Narayana V, de Souza D, Mason J, McLean C, et al.
Metabolites
. 2022 Jun;
12(6).
PMID: 35736487
Lipid metabolism is profoundly dysregulated in amyotrophic lateral sclerosis (ALS), yet the lipid composition of the white matter, where the myelinated axons of motor neurons are located, remains uncharacterised. We...
10.
Teyssou E, Chartier L, Roussel D, Perera N, Nemazanyy I, Langui D, et al.
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628504
Mutations in profilin 1 (PFN1) have been identified in rare familial cases of Amyotrophic Lateral Sclerosis (ALS). PFN1 is involved in multiple pathways that could intervene in ALS pathology. However,...