Chau-To Kwok
Overview
Explore the profile of Chau-To Kwok including associated specialties, affiliations and a list of published articles.
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16
Citations
536
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Recent Articles
1.
Green I, Pinello N, Song R, Lee Q, Halstead J, Kwok C, et al.
Nucleic Acids Res
. 2020 May;
48(12):6513-6529.
PMID: 32449925
Monocytes and macrophages are essential components of the innate immune system. Herein, we report that intron retention (IR) plays an important role in the development and function of these cells....
2.
Wong J, Gao D, Nguyen T, Kwok C, van Geldermalsen M, Middleton R, et al.
Nat Commun
. 2017 May;
8:15134.
PMID: 28480880
While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR....
3.
Kwok C, Marshall A, Rasko J, Wong J
J Hematol Oncol
. 2017 Feb;
10(1):49.
PMID: 28212678
No abstract available.
4.
Kwok C, Marshall A, Rasko J, Wong J
J Hematol Oncol
. 2017 Feb;
10(1):39.
PMID: 28153030
Methylation of N adenosine (mA) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in...
5.
Hesson L, Ng B, Zarzour P, Srivastava S, Kwok C, Packham D, et al.
Mol Cancer Res
. 2016 Sep;
14(12):1217-1228.
PMID: 27671336
Implications: The novel genetic, epigenetic, and transcriptional changes associated with LST development reveal important insights into why some adenomas do not progress to cancer. The finding that LSTs exhibit a...
6.
Wong J, Au A, Gao D, Pinello N, Kwok C, Thoeng A, et al.
Nucleic Acids Res
. 2016 Jan;
44(6):2888-97.
PMID: 26825461
Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We...
7.
Sloane M, Nunez A, Packham D, Kwok C, Suthers G, Hesson L, et al.
JAMA Oncol
. 2015 Jul;
1(7):953-7.
PMID: 26181641
Importance: Constitutional hypermethylation of 1 allele throughout the soma (constitutional epimutation) is an accepted mechanism of cancer predisposition. Understanding the origin and inheritance of epimutations is important for assessing cancer...
8.
Kwok C, Hitchins M
Methods Mol Biol
. 2015 Jun;
1315:153-71.
PMID: 26103898
Pyrosequencing(®) is able to quantitate the level of a nucleotide at a designated germ-line or somatic variant, including single nucleotide polymorphisms (SNPs). SNPs within a gene of interest may be...
9.
Hesson L, Packham D, Kwok C, Nunez A, Ng B, Schmidt C, et al.
Hum Mutat
. 2015 Mar;
36(6):622-30.
PMID: 25762362
Lynch syndrome is a hereditary cancer syndrome caused by a constitutional mutation in one of the mismatch repair genes. The implementation of predictive testing and targeted preventative surveillance is hindered...
10.
Kwok C, Vogelaar I, van Zelst-Stams W, Mensenkamp A, Ligtenberg M, Rapkins R, et al.
Eur J Hum Genet
. 2013 Oct;
22(5):617-24.
PMID: 24084575
Germline mutations of the DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2, and deletions affecting the EPCAM gene adjacent to MSH2, underlie Lynch syndrome by predisposing to early-onset colorectal,...