Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2016 Sep 28

PMID 27671336

Citations 13

Authors

Luke B Hesson

Benedict Ng

Peter Zarzour

Sameer Srivastava

Chau-To Kwok

Deborah Packham

Andrea C Nunez

Dominik Beck

Regina Ryan

Ashraf Dower

Caroline E Ford

John E Pimanda

Mathew A Sloane

Nicholas J Hawkins

Michael J Bourke

Jason W H Wong

Robyn L Ward

Affiliations

Soon will be listed here.

Abstract

Implications: The novel genetic, epigenetic, and transcriptional changes associated with LST development reveal important insights into why some adenomas do not progress to cancer. The finding that LSTs exhibit a mutational load similar to colorectal carcinomas has implications for the validity of molecular biomarkers for assessing cancer risk. Mol Cancer Res; 14(12); 1217-28. ©2016 AACR.

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