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Charles C T Hindmarch

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Articles 34
Citations 454
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Recent Articles
1.
Shastry A, Wilkinson M, Miller D, Kuriakose M, Veeneman J, Smith M, et al.
Redox Biol . 2025 Feb; 81:103541. PMID: 39983345
Rationale: Excess consumption of sugar- and fat-rich foods has heightened the prevalence of cardiometabolic disease, which remains a driver of cardiovascular disease- and type II diabetes-related mortality globally. Skeletal muscle...
2.
Ferrario C, Mackey J, Gelmon K, LeVasseur N, Sorensen P, Oo H, et al.
Clin Cancer Res . 2024 Nov; 31(3):491-502. PMID: 39576211
Purpose: Preclinical data motivate clinical evaluation of inhibitors of MAPK-interacting kinases 1 and 2 (MNK1/2). We conducted a phase 1b clinical trial to study target engagement and safety of tomivosertib,...
3.
Pare J, Tabasinezhad M, Grossman A, Atallah A, Hindmarch C, Tyryshkin K, et al.
Bladder Cancer . 2024 Jul; 9(2):175-186. PMID: 38993297
Background: The mode of action of Bacillus Calmette-Guérin (BCG) in the treatment of patients with non-muscle invasive bladder cancer (NMIBC) is incompletely understood, but recent studies support an association between...
4.
Bentley R, Hindmarch C, Archer S
Semin Perinatol . 2023 Mar; 47(2):151715. PMID: 36906478
The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance...
5.
Choi S, Dwyer C, Rapkin L, Cormier M, Hindmarch C, Nesbitt K, et al.
J Thromb Haemost . 2023 Jan; 21(3):586-598. PMID: 36696220
Background: Although the concept of immunothrombosis has established a link between inflammation and thrombosis, the role of inflammation in the pathogenesis of deep vein thrombosis remains to be fully elucidated....
6.
Mason E, Hindmarch C, Dunham-Snary K
Endocrinol Diabetes Metab . 2022 Oct; 6(1):e385. PMID: 36300606
Introduction: Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) is the most common inherited metabolic disorder of β-oxidation. Patients with MCADD present with hypoketotic hypoglycemia, which may quickly progress to lethargy, coma, and...
7.
Kloosterman R, Zago-Schmitt M, Grabell J, Thibeault L, De Lima P, Bowman M, et al.
Blood Adv . 2022 Sep; 7(8):1477-1487. PMID: 36121439
Type 1 von Willebrand disease (VWD) is associated with a reduction in qualitatively normal von Willebrand factor (VWF). Current diagnostic guidelines only take into consideration the contribution of basal VWF...
8.
Bentley R, Hindmarch C, Dunham-Snary K, Snetsinger B, Mewburn J, Thebaud A, et al.
Data Brief . 2022 Jan; 40:107736. PMID: 35005134
The Ductus Arteriosus (DA) is a fetal vessel that connects the aorta to the pulmonary artery ensuring that placental oxygenated blood is diverted from the lungs to the systemic circulation....
9.
Liblik K, Mulvagh S, Hindmarch C, Alavi N, Johri A
Trends Cardiovasc Med . 2021 Aug; 32(6):341-347. PMID: 34363978
Cardiovascular disease is the leading global cause of mortality, with ischemic heart disease causing the majority of cardiovascular deaths. Despite this, diagnostic delay commonly occurs in women experiencing acute myocardial...
10.
Pauza A, Mecawi A, Paterson A, Hindmarch C, Greenwood M, Murphy D, et al.
J Neuroendocrinol . 2021 Jul; 33(8):e13007. PMID: 34297454
The hypothalamic supraoptic nucleus (SON) is a core osmoregulatory control centre that deciphers information about the metabolic state of the organism and orchestrates appropriate homeostatic (endocrine) and allostatic (behavioural) responses....