Charles B Epstein
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Explore the profile of Charles B Epstein including associated specialties, affiliations and a list of published articles.
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33
Citations
10166
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Recent Articles
1.
Schreiber J, Boix C, Wook Lee J, Li H, Guan Y, Chang C, et al.
Genome Biol
. 2025 Feb;
26(1):31.
PMID: 39948633
No abstract available.
2.
Moore M, Wekhande S, Issner R, Collins A, Cruz A, Liu Y, et al.
Nat Commun
. 2025 Feb;
16(1):1357.
PMID: 39905017
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity...
3.
Hu Y, Horlbeck M, Zhang R, Ma S, Shrestha R, Kartha V, et al.
Nature
. 2025 Jan;
638(8051):779-786.
PMID: 39843737
Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function, reflecting changes in the composition of diverse effector proteins over time. However, methods for measuring the...
4.
Moore J, Pratt H, Fan K, Phalke N, Fisher J, Elhajjajy S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763870
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated...
5.
Sumida T, Lincoln M, He L, Park Y, Ota M, Oguchi A, et al.
Sci Transl Med
. 2024 Aug;
16(762):eadp1720.
PMID: 39196959
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4FOXP3 regulatory T cells (T) play a central role in preventing autoimmunity,...
6.
Jung Y, Zhao W, Li I, Jain D, Epstein C, Bernstein B, et al.
Nat Commun
. 2024 Mar;
15(1):2106.
PMID: 38453887
In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple...
7.
Dolan M, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, et al.
Nat Immunol
. 2023 Jul;
24(8):1382-1390.
PMID: 37500887
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes known as states. Understanding state function, especially...
8.
Schreiber J, Schreiber J, Boix C, Boix C, Wook Lee J, Li H, et al.
Genome Biol
. 2023 Apr;
24(1):79.
PMID: 37072822
A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to impute the remainder. However, identifying the best imputation methods...
9.
Hu Y, Ma S, Kartha V, Duarte F, Horlbeck M, Zhang R, et al.
bioRxiv
. 2023 Apr;
PMID: 37034577
-regulatory elements control gene expression and are dynamic in their structure, reflecting changes to the composition of diverse effector proteins over time. Here we sought to connect the structural changes...
10.
Rozowsky J, Gao J, Borsari B, Yang Y, Galeev T, Gursoy G, et al.
Cell
. 2023 Mar;
186(7):1493-1511.e40.
PMID: 37001506
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource...