Chang Siang Lim
Overview
Explore the profile of Chang Siang Lim including associated specialties, affiliations and a list of published articles.
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10
Citations
184
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Recent Articles
1.
Castro O, Mair J, Salamanca-Sanabria A, Alattas A, Keller R, Zheng S, et al.
Front Digit Health
. 2023 May;
5:1039171.
PMID: 37234382
Background: Non-communicable diseases (NCDs) and common mental disorders (CMDs) are the leading causes of death and disability worldwide. Lifestyle interventions mobile apps and conversational agents present themselves as low-cost, scalable...
2.
Surendran S, Lim C, Koh G, Yew T, Tai E, Foong P
Int J Environ Res Public Health
. 2021 Jul;
18(12).
PMID: 34205744
The prevalence of gestational diabetes mellitus (GDM) is increasing, and only a few mobile health (mHealth) applications are specifically designed to manage GDM. In this mixed-methods study, a follow-up study...
3.
Low B, Lim C, Ding S, Sing Tan Y, Ng N, Krishnan V, et al.
Nat Commun
. 2021 May;
12(1):3133.
PMID: 34035238
Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3 (MODY3), characterized by insulin secretion defects. However, specific mechanisms of MODY3 in humans remain unclear due to...
4.
Teo A, Nguyen L, Gupta M, Lau H, Loo L, Jackson N, et al.
J Biol Chem
. 2021 Mar;
296:100495.
PMID: 33667549
Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying...
5.
Yew T, Chi C, Chan S, van Dam R, Whitton C, Lim C, et al.
Diabetes Care
. 2020 Nov;
44(2):456-463.
PMID: 33184151
Objective: SMART-GDM examined whether Habits-GDM, a smartphone application (app) coaching program, can prevent excessive gestational weight gain (EGWG) and improve glycemic control and maternal and neonatal outcomes in gestational diabetes...
6.
Tan E, Hopkins R, Lim C, Jamuar S, Ong C, Thoon K, et al.
J Clin Invest
. 2020 Aug;
130(11):5817-5832.
PMID: 32750042
Although IKK-β has previously been shown as a negative regulator of IL-1β secretion in mice, this role has not been proven in humans. Genetic studies of NF-κB signaling in humans...
7.
Kang N, Lee J, Lee S, Song I, Hwang Y, Kim M, et al.
J Am Chem Soc
. 2020 Feb;
142(7):3430-3439.
PMID: 32040300
Pancreatic β cells are responsible for insulin secretion and are important for glucose regulation in a healthy body and diabetic disease patient without prelabeling of islets. While the conventional biomarkers...
8.
Ng N, Jasmen J, Lim C, Lau H, Krishnan V, Kadiwala J, et al.
iScience
. 2019 Jun;
16:192-205.
PMID: 31195238
Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development of...
9.
Teo A, Lim C, Cheow L, Kin T, Shapiro J, Kang N, et al.
Cell Death Discov
. 2018 Mar;
4:14.
PMID: 29531811
Human pancreatic islets containing insulin-secreting β-cells are notoriously heterogeneous in cell composition. Since β-cell failure is the root cause of diabetes, understanding this heterogeneity is of paramount importance. Recent reports...
10.
Loo L, Lau H, Jasmen J, Lim C, Teo A
Diabetes Obes Metab
. 2017 May;
20(1):3-13.
PMID: 28474496
Type 1 and type 2 diabetes are caused by a destruction and decrease in the number of functional insulin-producing β cells, respectively; therefore, the generation of functional β cells from...