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Adrian Kee Keong Teo

Explore the profile of Adrian Kee Keong Teo including associated specialties, affiliations and a list of published articles. Areas
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Articles 51
Citations 836
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Recent Articles
1.
Tan W, Lim L, Afsha N, Chan G, Ching C, Oguz G, et al.
PNAS Nexus . 2025 Feb; 4(2):pgae568. PMID: 39990763
, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in...
2.
Tan L, Lau H, Abdelalim E, Khoo C, OBrien R, Tai E, et al.
Trends Mol Med . 2024 Oct; 31(2):152-164. PMID: 39426930
Glucose-6-phosphatase catalytic subunit (G6PC)1 and G6PC2 are crucial for glucose metabolism, regulating processes like glycolysis, gluconeogenesis, and glycogenolysis. Despite their structural and functional similarities, G6PC1 and G6PC2 exhibit distinct tissue-specific...
3.
Pamies D, Ekert J, Zurich M, Frey O, Werner S, Piergiovanni M, et al.
Stem Cell Reports . 2024 Jul; PMID: 38959889
No abstract available.
4.
Ng N, Ghosh S, Bok C, Ching C, Low B, Chen J, et al.
Nat Commun . 2024 Jun; 15(1):4288. PMID: 38909044
HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver. Mutations in both genes have been directly linked to Maturity Onset...
5.
Leow D, Ng Y, Wang L, Koh H, Zhao T, Khong Z, et al.
J Clin Invest . 2024 May; 134(12). PMID: 38722695
Spinal muscular atrophy (SMA) is typically characterized as a motor neuron disease, but extraneuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extraneuronal phenotypes...
6.
Pamies D, Ekert J, Zurich M, Frey O, Werner S, Piergiovanni M, et al.
Stem Cell Reports . 2024 Apr; 19(5):604-617. PMID: 38670111
Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological...
7.
Ho B, Teo A, Ng N
Front Immunol . 2024 Apr; 15:1375177. PMID: 38650946
Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high risk of severe hypoglycemia. However, intensive...
8.
Autio M, Motakis E, Perrin A, Bin Amin T, Tiang Z, Do D, et al.
Elife . 2024 Jan; 13. PMID: 38164941
Selection of the target site is an inherent question for any project aiming for directed transgene integration. Genomic safe harbour (GSH) loci have been proposed as safe sites in the...
9.
Lau H, Krentz N, Abaitua F, Perez-Alcantara M, Chan J, Ajeian J, et al.
Nat Commun . 2023 Sep; 14(1):6119. PMID: 37777536
The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for...
10.
Lau H, Amirruddin N, Loo L, Chan J, Iich E, Krishnan V, et al.
iScience . 2023 Jul; 26(8):107265. PMID: 37502260
The differentiation of human pluripotent stem cells into the SOX17 definitive endoderm (DE) germ layer is important for generating tissues for regenerative medicine. Multiple developmental and stem cell studies have...