Chad R Hancock
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Explore the profile of Chad R Hancock including associated specialties, affiliations and a list of published articles.
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38
Citations
963
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Recent Articles
11.
Hafen P, Abbott K, Bowden J, Lopiano R, Hancock C, Hyldahl R
J Appl Physiol (1985)
. 2019 May;
127(1):47-57.
PMID: 31046520
Skeletal muscle immobilization leads to atrophy, decreased metabolic health, and substantial losses in function. Animal models suggest that heat stress can provide protection against atrophy in skeletal muscle. This study...
12.
Koh J, Hancock C, Han D, Holloszy J, Nair K, Dasari S
Am J Physiol Endocrinol Metab
. 2019 Mar;
316(5):E931-E939.
PMID: 30888859
The objective of this study is to determine whether AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), or peroxisome proliferator-activated receptor β (PPARβ) can independently mediate the...
13.
Mackay A, Marchant E, Munk D, Watt R, Hansen J, Thomson D, et al.
Am J Physiol Endocrinol Metab
. 2019 Mar;
316(5):E922-E930.
PMID: 30888858
Doxorubicin (DOX) is an effective chemotherapeutic treatment with lasting side effects in heart and skeletal muscle. DOX is known to bind with iron, contributing to oxidative damage resulting in cardiac...
14.
Hafen P, Preece C, Sorensen J, Hancock C, Hyldahl R
J Appl Physiol (1985)
. 2018 Jul;
125(5):1447-1455.
PMID: 30024339
The heat stress response is associated with several beneficial adaptations that promote cell health and survival. Specifically, in vitro and animal investigations suggest that repeated exposures to a mild heat...
15.
Deyhle M, Hafen P, Parmley J, Preece C, Robison M, Sorensen J, et al.
Physiol Rep
. 2018 Apr;
6(8):e13689.
PMID: 29696819
CXCL10 is a chemokine for activated and memory T cells with many important immunological functions. We recently found that CXCL10 is upregulated in human muscle following contraction-induced damage. No information...
16.
Kener K, Munk D, Hancock C, Tessem J
J Vis Exp
. 2018 Feb;
(131).
PMID: 29443067
High-resolution respirometry allows for the measurement of oxygen consumption of isolated mitochondria, cells and tissues. Beta cells play a critical role in the body by controlling blood glucose levels through...
17.
Tueller D, Harley J, Hancock C
Biochem Biophys Res Commun
. 2017 Aug;
492(3):368-372.
PMID: 28847726
Curcumin may improve blood glucose management, but the mechanism is not fully established. We demonstrated that curcumin (40 μM) reduced the mitochondrial coupling efficiency (percentage of oxygen consumption coupled to...
18.
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D
Cell Metab
. 2017 May;
25(5):1176-1185.e5.
PMID: 28467933
The objective of this study was to evaluate the specific mechanism(s) by which PPARβ regulates mitochondrial content in skeletal muscle. We discovered that PPARβ increases PGC-1α by protecting it from...
19.
Reynolds M, Hancock C, Ray J, Kener K, Draney C, Garland K, et al.
Am J Physiol Endocrinol Metab
. 2016 May;
311(1):E186-201.
PMID: 27221116
β-Cell insulin secretion is dependent on proper mitochondrial function. Various studies have clearly shown that the Nr4a family of orphan nuclear receptors is essential for fuel utilization and mitochondrial function...
20.
Chen T, Moore T, Ebbert M, McVey N, Madsen S, Hallowell D, et al.
J Appl Physiol (1985)
. 2016 Jan;
120(8):876-88.
PMID: 26796753
Skeletal muscle-specific liver kinase B1 (LKB1) knockout mice (skmLKB1-KO) exhibit elevated mitogen-activated protein kinase (MAPK) signaling after treadmill running. MAPK activation is also associated with inflammation-related signaling in skeletal muscle....