Caryn R Hale
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Explore the profile of Caryn R Hale including associated specialties, affiliations and a list of published articles.
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11
Citations
924
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Recent Articles
1.
Bai Z, Bartelo N, Aslam M, Murphy E, Hale C, Blachere N, et al.
Sci Transl Med
. 2024 Apr;
16(742):eadk3506.
PMID: 38598614
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal that pain scores in patients do not correlate with...
2.
Hacisuleyman E, Hale C, Noble N, Luo J, Fak J, Saito M, et al.
Nat Neurosci
. 2024 Apr;
27(5):822-835.
PMID: 38589584
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear. In this study, to monitor how depolarization impacts local...
3.
Irmady K, Hale C, Qadri R, Fak J, Simelane S, Carroll T, et al.
Nat Commun
. 2023 Jul;
14(1):3956.
PMID: 37407548
The ability to use blood to predict the outcomes of Parkinson's disease, including disease progression and cognitive and motor complications, would be of significant clinical value. We undertook bulk RNA...
4.
Brewer R, Lanz T, Hale C, Sepich-Poore G, Martino C, Swafford A, et al.
Sci Transl Med
. 2023 Feb;
15(684):eabq8476.
PMID: 36812347
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis...
5.
Hale C, Sawicka K, Mora K, Fak J, Kang J, Cutrim P, et al.
Elife
. 2021 Dec;
10.
PMID: 34939924
Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification...
6.
Showalter K, Spiera R, Magro C, Agius P, Martyanov V, Franks J, et al.
Ann Rheum Dis
. 2020 Oct;
80(2):228-237.
PMID: 33028580
Objective: We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma). Methods: Fifty-eight forearm biopsies were evaluated from 26 individuals...
7.
Sawicka K, Hale C, Park C, Fak J, Gresack J, Van Driesche S, et al.
Elife
. 2019 Dec;
8.
PMID: 31860442
Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP function varies across brain...
8.
Hale C, Cocozaki A, Li H, Terns R, Terns M
Genes Dev
. 2014 Nov;
28(21):2432-43.
PMID: 25367038
The effector complex of the Cmr/type III-B CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR-associated) system cleaves RNAs recognized by the CRISPR RNA (crRNA) of the complex and includes six...
9.
Cocozaki A, Ramia N, Shao Y, Hale C, Terns R, Terns M, et al.
Structure
. 2012 Mar;
20(3):545-53.
PMID: 22405013
Cmr2 is the largest and an essential subunit of a CRISPR RNA-Cas protein complex (the Cmr complex) that cleaves foreign RNA to protect prokaryotes from invading genetic elements. Cmr2 is...
10.
Hale C, Majumdar S, Elmore J, Pfister N, Compton M, Olson S, et al.
Mol Cell
. 2012 Jan;
45(3):292-302.
PMID: 22227116
Small RNAs target invaders for silencing in the CRISPR-Cas pathways that protect bacteria and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence elements acquired from invaders that...