Robert B Darnell
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Explore the profile of Robert B Darnell including associated specialties, affiliations and a list of published articles.
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152
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15586
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Recent Articles
1.
Tajima Y, Vargas C, Ito K, Wang W, Luo J, Xing J, et al.
Nat Commun
. 2025 Feb;
16(1):1542.
PMID: 39966351
NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival in mice and normal development in humans. A single amino acid change (I197V) in NOVA1's...
2.
Singer R, Rajchin V, Park K, Heintz N, Darnell R
bioRxiv
. 2024 Aug;
PMID: 39185177
Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are disrupted in Fragile X Syndrome...
3.
Bai Z, Bartelo N, Aslam M, Murphy E, Hale C, Blachere N, et al.
Sci Transl Med
. 2024 Apr;
16(742):eadk3506.
PMID: 38598614
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal that pain scores in patients do not correlate with...
4.
Hacisuleyman E, Hale C, Noble N, Luo J, Fak J, Saito M, et al.
Nat Neurosci
. 2024 Apr;
27(5):822-835.
PMID: 38589584
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear. In this study, to monitor how depolarization impacts local...
5.
Saito Y, Yang Y, Saito M, Park C, Funato K, Tabar V, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(10):e2314695121.
PMID: 38416679
NOVA1 is a neuronal RNA-binding protein identified as the target antigen of a rare autoimmune disorder associated with cancer and neurological symptoms, termed paraneoplastic opsoclonus-myoclonus ataxia. Despite the strong association...
6.
Taylor S, Kobayashi M, Vilella A, Tiwari D, Zolboot N, Du J, et al.
Elife
. 2023 Oct;
12.
PMID: 37862092
The assembly of the mammalian brain is orchestrated by temporally coordinated waves of gene expression. Post-transcriptional regulation by microRNAs (miRNAs) is a key aspect of this program. Indeed, deletion of...
7.
Irmady K, Hale C, Qadri R, Fak J, Simelane S, Carroll T, et al.
Nat Commun
. 2023 Jul;
14(1):3956.
PMID: 37407548
The ability to use blood to predict the outcomes of Parkinson's disease, including disease progression and cognitive and motor complications, would be of significant clinical value. We undertook bulk RNA...
8.
Ibrahim L, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, et al.
Elife
. 2023 Jun;
12.
PMID: 37347149
Somatostatin interneurons are the earliest born population of cortical inhibitory cells. They are crucial to support normal brain development and function; however, the mechanisms underlying their integration into nascent cortical...
9.
Brewer R, Lanz T, Hale C, Sepich-Poore G, Martino C, Swafford A, et al.
Sci Transl Med
. 2023 Feb;
15(684):eabq8476.
PMID: 36812347
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis...
10.
Tajima Y, Ito K, Yuan Y, Frank M, Saito Y, Darnell R
Cell Rep
. 2023 Jan;
42(2):112050.
PMID: 36716149
We describe a patient haploinsufficient for the neuronal RNA binding protein NOVA1 who developed a behavioral motor hyperactivity disorder, suggesting a role of NOVA1 in postnatal motor inhibition. To investigate...