Caroll B Hartline
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Explore the profile of Caroll B Hartline including associated specialties, affiliations and a list of published articles.
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35
Citations
696
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Recent Articles
1.
Yang J, Riemann S, Lyu J, Feng S, Bi Y, Lentini N, et al.
bioRxiv
. 2024 Nov;
PMID: 39554161
Adenovirus infections of immunocompromised humans are a significant source of morbidity and mortality. At present, no drug has been approved by FDA for the treatment of adenovirus infections. A current...
2.
Kovalishyn V, Severin O, Kachaeva M, Kobzar O, Keith K, Harden E, et al.
Mol Biotechnol
. 2023 Jan;
66(4):707-717.
PMID: 36709460
Varicella zoster virus (VZV) infection causes severe disease such as chickenpox, shingles, and postherpetic neuralgia, often leading to disability. Reactivation of latent VZV is associated with a decrease in specific...
3.
Lipka E, Chadderdon A, Harteg C, Doherty M, Simon E, Domagala J, et al.
Mol Pharm
. 2022 Dec;
20(1):370-382.
PMID: 36484496
DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV)...
4.
Keith K, Hartline C, Bowlin T, Prichard M
Antiviral Res
. 2018 Oct;
159:122-129.
PMID: 30287227
The search for new compounds with a broad spectrum of antiviral activity is important and requires the evaluation of many compounds against several distinct viruses. Researchers attempting to develop new...
5.
Hartline C, Keith K, Eagar J, Harden E, Bowlin T, Prichard M
Antiviral Res
. 2018 Oct;
159:104-112.
PMID: 30287226
The search for new compounds with a broad spectrum of antiviral activity is important and requires the evaluation of many compounds against several distinct viruses. Researchers attempting to develop new...
6.
Hartline C, Conner R, James S, Potter J, Gray E, Estrada J, et al.
Xenotransplantation
. 2018 Sep;
25(4):e12427.
PMID: 30264882
Background: Recent advances in xenotransplantation have produced organs from pigs that are well tolerated in primate models because of genetic changes engineered to delete major antigens from donor animals. To...
7.
Toth K, Spencer J, Ying B, Tollefson A, Hartline C, Richard E, et al.
Antiviral Res
. 2018 Mar;
153:1-9.
PMID: 29510156
Human adenoviruses (AdV) cause generally mild infections of the respiratory and GI tracts as well as some other tissues. However, AdV can cause serious infection in severely immunosuppressed individuals, especially...
8.
Manos-Turvey A, Al-Ashtal H, Needham P, Hartline C, Prichard M, Wipf P, et al.
Bioorg Med Chem Lett
. 2016 Sep;
26(20):5087-5091.
PMID: 27624078
Human polyomaviruses are generally latent but can be reactivated in patients whose immune systems are suppressed. Unfortunately, current therapeutics for diseases associated with polyomaviruses are non-specific, have undefined mechanisms of...
9.
Komazin-Meredith G, Cardinale S, Comeau K, Magalhaes K, Hartline C, Williams J, et al.
Antiviral Res
. 2015 Apr;
119:23-7.
PMID: 25857706
Monohydroxymethyl methylenecyclopropane nucleosides (MCPNs) with ether or thioether substituents at the 6-position show promise as broad-spectrum herpes virus inhibitors. Their proposed mechanism of action involves sequential phosphorylation to a triphosphate,...
10.
Komazin-Meredith G, Chou S, Prichard M, Hartline C, Cardinale S, Comeau K, et al.
Antimicrob Agents Chemother
. 2013 Oct;
58(1):274-8.
PMID: 24145545
Methylenecyclopropane nucleoside (MCPN) analogs are being investigated for treatment of human cytomegalovirus (HCMV) infection because of favorable preclinical data and limited ganciclovir cross-resistance. Monohydroxymethyl MCPNs bearing ether and thioether functionalities...