Carmen Fernandez-Metzler
Overview
Explore the profile of Carmen Fernandez-Metzler including associated specialties, affiliations and a list of published articles.
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25
Citations
94
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Recent Articles
1.
Vazvaei-Smith F, Li W, Barnaby O, Bhardwaj S, Dong J, Dumont C, et al.
AAPS J
. 2025 Mar;
27(2):57.
PMID: 40069400
The analysis of Non-Liquid Matrices (NLMs) can provide key information on many aspects in drug discovery and development. These include but are not limited to drug uptake and distribution, engagement...
2.
Metzler G, King R, Fernandez-Metzler C, Das A, Davis T, Bajrami B, et al.
Methods Mol Biol
. 2024 Oct;
2855:341-354.
PMID: 39354317
Bioactive lipid mediators derived from arachidonic acid constitute an attractive pool of metabolites that reflect cellular function and signaling, as well as potential biomarkers that may respond quantitatively to disease...
3.
Metzler G, Day L, King R, Fernandez-Metzler C, Das A, Davis T, et al.
Methods Mol Biol
. 2024 Oct;
2855:147-154.
PMID: 39354306
The analysis of prostaglandin urinary metabolites is valuable for assessing physiological processes and identifying disease biomarkers. These metabolites, derived from the breakdown of prostaglandins, offer a noninvasive means to gauge...
4.
Fernandez-Metzler C, Ackermann B, Garofolo F, Arnold M, DeSilva B, Gu H, et al.
AAPS J
. 2022 May;
24(3):66.
PMID: 35534647
Decades of discussion and publication have gone into the guidance from the scientific community and the regulatory agencies on the use and validation of pharmacokinetic and toxicokinetic assays by chromatographic...
5.
Hays A, Amaravadi L, Fernandez-Metzler C, King L, Mathews J, Ni Y, et al.
AAPS J
. 2022 May;
24(3):65.
PMID: 35511303
No abstract available.
6.
Metzler G, Crathern S, Bachmann L, Fernandez-Metzler C, King R
J Am Soc Mass Spectrom
. 2017 Jul;
28(10):2117-2123.
PMID: 28730543
A method for continuously monitoring the performance of electrospray ionization without the addition of hardware or chemistry to the system is demonstrated. In the method, which we refer to as...
7.
King R, Fernandez-Metzler C, Bachmann L
Bioanalysis
. 2016 Oct;
8(22):2291-2293.
PMID: 27704868
No abstract available.
8.
Lassman M, Fernandez-Metzler C
Bioanalysis
. 2014 Aug;
6(13):1859-67.
PMID: 25157490
Although ligand-binding assays are frequently employed to measure large molecules, the use of LC-SRM assays is increasingly popular due to the inherent selectivity advantage and the ability to operate without...
9.
McDonnell M, Vera M, Blass B, Pelletier J, King R, Fernandez-Metzler C, et al.
Bioorg Med Chem
. 2012 Aug;
20(18):5642-8.
PMID: 22892214
Riluzole (1) is an approved therapeutic for the treatment of ALS and has also demonstrated anti-melanoma activity in metabotropic glutamate GRM1 positive cell lines, a mouse xenograft assay and human...
10.
Cox C, Coleman P, Breslin M, Whitman D, Garbaccio R, Fraley M, et al.
J Med Chem
. 2008 Jun;
51(14):4239-52.
PMID: 18578472
Inhibition of kinesin spindle protein (KSP) is a novel mechanism for treatment of cancer with the potential to overcome limitations associated with currently employed cytotoxic agents. Herein, we describe a...