Carlos J Orihuela
Overview
Explore the profile of Carlos J Orihuela including associated specialties, affiliations and a list of published articles.
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102
Citations
3877
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Recent Articles
1.
Olivella-Gomez J, Lozada J, Serrano-Mayorga C, Mendez-Castillo L, Acosta-Gonzalez A, Vinan Garces A, et al.
PLoS One
. 2025 Feb;
20(2):e0318320.
PMID: 39937814
Purpose: Streptococcus pneumoniae (Spn) is the primary bacterial cause of lower respiratory tract infections (LRTI) globally, particularly impacting older adults and children. While Spn colonization in children is linked to...
2.
Martinez E, Im H, Campos-Gomez J, Orihuela C
Res Sq
. 2024 Oct;
PMID: 39399664
Following severe burn injury, is the leading cause of life-threatening infection. Herein, we unveil how strategically employs host-derived oleic acid, released as consequence of burn-injury, to induce a hypervirulent phenotype...
3.
Chembilikandy V, DMello A, Tettelin H, Martinez E, Orihuela C
Appl Environ Microbiol
. 2024 Aug;
90(9):e0101024.
PMID: 39140740
Importance: We introduce a new strategy aimed at streamlining the process for marker-less allelic replacement in , a Gram-positive bacterium and leading cause of pneumonia, meningitis, and ear infections. Our...
4.
Hiller N, Orihuela C
J Bacteriol
. 2024 May;
206(6):e0005924.
PMID: 38809015
The major human pathogen has been the subject of intensive clinical and basic scientific study for over 140 years. In multiple instances, these efforts have resulted in major breakthroughs in...
5.
Kruckow K, Murray E, Shayhidin E, Rosenberg A, Bowdish D, Orihuela C
Aging Cell
. 2024 Mar;
23(6):e14133.
PMID: 38459711
Chronic low-grade inflammation, particularly elevated tumor necrosis factor (TNF) levels, occurs due to advanced age and is associated with greater susceptibility to infection. One reason for this is age-dependent macrophage...
6.
Minassian D, Shan L, Dong C, Charania A, Orihuela C, He C
Am J Med Sci
. 2024 Feb;
367(5):304-309.
PMID: 38340982
Background: Streptococcus pneumoniae (Spn) infection remains common worldwide despite recent vaccine efforts. Invasive pneumococcal disease (IPD) is the most severe form of Spn infection. Known individual risk factors for IPD...
7.
Lane J, Tata M, Yasmin R, Im H, Briles D, Orihuela C
mBio
. 2023 Nov;
14(6):e0263423.
PMID: 37982608
is a dangerous human pathogen capable of causing pneumonia and invasive disease. The virulence factor PspA has been studied for nearly four decades with well-established roles in pneumococcal evasion of...
8.
Lane J, Tata M, Yasmin R, Im H, Briles D, Orihuela C
bioRxiv
. 2023 Oct;
PMID: 37808718
() resides in the nasopharynx where it can disseminate to cause disease. One key virulence factor is pneumococcal surface protein A (PspA), which promotes survival by blocking the antimicrobial peptide...
9.
Patton M, Gaggar A, Might M, Erdmann N, Orihuela C, Harrod K
Physiol Rev
. 2023 Aug;
104(1):1-21.
PMID: 37589392
No abstract available.
10.
Earnhardt E, Tipper J, DMello A, Jian M, Conway E, Mobley J, et al.
JCI Insight
. 2023 Jun;
8(14).
PMID: 37318849
Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections that lead to increased morbidity and mortality. Our recent work demonstrates that IAV disrupts airway homeostasis, leading to...