Carl S Rye
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Explore the profile of Carl S Rye including associated specialties, affiliations and a list of published articles.
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12
Citations
124
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Recent Articles
1.
Pasqua A, Sharp S, Chessum N, Hayes A, Pellegrino L, Tucker M, et al.
J Med Chem
. 2023 Apr;
66(8):5907-5936.
PMID: 37017629
CCT251236 , a potent chemical probe, was previously developed from a cell-based phenotypic high-throughput screen (HTS) to discover inhibitors of transcription mediated by HSF1, a transcription factor that supports malignancy....
2.
Meyers J, Chessum N, Ali S, Mok N, Wilding B, Pasqua A, et al.
ACS Med Chem Lett
. 2019 Jan;
9(12):1199-1204.
PMID: 30613326
Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9...
3.
Fok J, Hedayat S, Zhang L, Aronson L, Mirabella F, Pawlyn C, et al.
Clin Cancer Res
. 2018 Feb;
24(10):2395-2407.
PMID: 29391353
Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin, and is therefore susceptible to therapies targeting protein homeostasis. We hypothesized that heat shock factor 1 (HSF1) was...
4.
Cheeseman M, Chessum N, Rye C, Pasqua A, Tucker M, Wilding B, et al.
J Med Chem
. 2016 Dec;
60(1):180-201.
PMID: 28004573
Phenotypic screens, which focus on measuring and quantifying discrete cellular changes rather than affinity for individual recombinant proteins, have recently attracted renewed interest as an efficient strategy for drug discovery....
5.
Rye C, Chessum N, Lamont S, Pike K, Faulder P, Demeritt J, et al.
Medchemcomm
. 2016 Oct;
7(8):1580-1586.
PMID: 27746890
Heat shock factor 1 (HSF1) is a transcription factor that plays key roles in cancer, including providing a mechanism for cell survival under proteotoxic stress. Therefore, inhibition of the HSF1-stress...
6.
Robinson C, Rye C, Chessum N, Jones K
Org Biomol Chem
. 2015 Jun;
13(27):7402-7.
PMID: 26088610
β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using...
7.
Koehler M, Bergeron P, Choo E, Lau K, Ndubaku C, Dudley D, et al.
ACS Med Chem Lett
. 2014 Jun;
5(6):662-7.
PMID: 24944740
Because of the promise of BCL-2 antagonists in combating chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL), interest in additional selective antagonists of antiapoptotic proteins has grown. Beginning with a...
8.
Rye C, Matte A, Cygler M, Withers S
Chembiochem
. 2006 Mar;
7(4):631-7.
PMID: 16521140
Chondroitin AC lyase from Flavobacterium heparinum catalyses the degradation of chondroitin by an anionic E1cb elimination mechanism that involves proton abstraction from C5 of glucuronic acid. The lyase also carries...
9.
Rye C, Withers S
Carbohydr Res
. 2004 Mar;
339(3):699-703.
PMID: 15013408
A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active...
10.
Rye C, Withers S
Anal Biochem
. 2002 Sep;
308(1):77-82.
PMID: 12234466
Many techniques have been developed for the assay of polysaccharide lyases; however, none have allowed the measurement of defined and reproducible k(cat) and K(m) values due to the inhomogeneous nature...