Paul Workman
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Explore the profile of Paul Workman including associated specialties, affiliations and a list of published articles.
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305
Citations
13847
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Recent Articles
1.
Muller S, Sanfelice D, Workman P
Cancer Cell
. 2025 Feb;
43(3):323-327.
PMID: 40020670
Chemical probes are powerful small-molecule tools in fundamental and translational cancer research. They are highly versatile, complementing genetic technologies in the annotation of protein function, and invaluable in target validation...
2.
Newman J, Gavard A, Imprachim N, Aitkenhead H, Sheppard H, Te Poele R, et al.
Nat Commun
. 2025 Feb;
16(1):1596.
PMID: 39952925
Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed...
3.
Welti J, Bogdan D, Figueiredo I, Coleman I, Jimenez Vacas J, Liodaki K, et al.
Clin Cancer Res
. 2025 Jan;
PMID: 39787247
Purpose: Advanced prostate cancer (PCa) is invariably fatal with the androgen receptor (AR) being a major therapeutic target. AR signaling inhibitors have improved overall survival for men with advanced PCa,...
4.
Sanfelice D, Antolin A, Crisp A, Chen Y, Bellenie B, Brennan P, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D1663-D1669.
PMID: 39558166
The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection and use of small-molecule compounds that qualify as chemical probes. These high-quality...
5.
Gingrich P, Chitsazi R, Biswas A, Jiang C, Zhao L, Tym J, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D1287-D1294.
PMID: 39535036
canSAR (https://cansar.ai) continues to serve as the largest publicly available platform for cancer-focused drug discovery and translational research. It integrates multidisciplinary data from disparate and otherwise siloed public data sources...
6.
Workman P
Cancer Res
. 2023 Oct;
83(19):3170-3173.
PMID: 37779429
Following three decades of systematic primary empirical screening against mice bearing two transplantable murine leukemias, the NCI took the bold step of switching to a radically different approach-initial screening of...
7.
Mader M, Rudolph J, Hartung I, Uehling D, Workman P, Zuercher W
Cancer Discov
. 2023 Sep;
13(10):2150-2165.
PMID: 37712569
Significance: Validation of biological targets and pathways will be aided by a shared understanding of the criteria of potency, selectivity, and target engagement associated with small-molecule reagents ("chemical probes") that...
8.
Hartung I, Rudolph J, Mader M, Mulder M, Workman P
J Med Chem
. 2023 Jul;
66(14):9297-9312.
PMID: 37403870
Within druggable target space, new small-molecule modalities, particularly covalent inhibitors and targeted degraders, have expanded the repertoire of medicinal chemists. Molecules with such modes of action have a large potential...
9.
Pasqua A, Sharp S, Chessum N, Hayes A, Pellegrino L, Tucker M, et al.
J Med Chem
. 2023 Apr;
66(8):5907-5936.
PMID: 37017629
CCT251236 , a potent chemical probe, was previously developed from a cell-based phenotypic high-throughput screen (HTS) to discover inhibitors of transcription mediated by HSF1, a transcription factor that supports malignancy....
10.
di Micco P, Antolin A, Mitsopoulos C, Villasclaras-Fernandez E, Sanfelice D, Dolciami D, et al.
Nucleic Acids Res
. 2023 Jan;
51(D1):D1212-D1219.
PMID: 36624665
canSAR (https://cansar.ai) is the largest public cancer drug discovery and translational research knowledgebase. Now hosted in its new home at MD Anderson Cancer Center, canSAR integrates billions of experimental measurements...