Carl R Flannery
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Explore the profile of Carl R Flannery including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Li N, Rivera-Bermudez M, Zhang M, Tejada J, Glasson S, Collins-Racie L, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(8):3734-9.
PMID: 20133709
Osteoarthritis (OA), the most common arthritic condition in humans, is characterized by the progressive degeneration of articular cartilage accompanied by chronic joint pain. Inflammatory mediators, such as cytokines and prostaglandin...
12.
Chamberland A, Wang E, Jones A, Collins-Racie L, Lavallie E, Huang Y, et al.
J Biol Chem
. 2009 Aug;
284(40):27352-9.
PMID: 19657146
Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association with...
13.
Kisiday J, Lee J, Siparsky P, Frisbie D, Flannery C, Sandy J, et al.
Ann Biomed Eng
. 2009 May;
37(7):1368-75.
PMID: 19415495
This study investigated the role of matrix metalloproteases and aggrecanases during dynamic compression-induced aggrecan catabolism in chondrocyte-seeded self-assembling peptide hydrogel. One- to two-week-old bovine chondrocytes were encapsulated into peptide hydrogel...
14.
Flannery C, Zollner R, Corcoran C, Jones A, Root A, Rivera-Bermudez M, et al.
Arthritis Rheum
. 2009 Feb;
60(3):840-7.
PMID: 19248108
Objective: Lubricin, also referred to as superficial zone protein and PRG4, is a synovial glycoprotein that supplies a friction-resistant, antiadhesive coating to the surfaces of articular cartilage, thereby protecting against...
15.
Gleghorn J, Jones A, Flannery C, Bonassar L
Arthritis Rheum
. 2009 Jan;
60(2):440-9.
PMID: 19180510
Objective: To evaluate the functional effects of transforming growth factor beta1 (TGFbeta1), interleukin-1beta (IL-1beta), and oncostatin M (OSM) on the frictional properties of articular cartilage and to determine the role...
16.
Jones A, Chen S, Chai D, Stevens A, Gleghorn J, Bonassar L, et al.
Arthritis Rheum
. 2009 Jan;
60(1):133-42.
PMID: 19116897
Objective: To evaluate the effects of injurious compression on the biosynthesis of lubricin at different depths within articular cartilage and to examine alterations in structure and function of the articular...
17.
Gleghorn J, Jones A, Flannery C, Bonassar L
J Orthop Res
. 2008 Dec;
27(6):771-7.
PMID: 19058183
Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin...
18.
Gilbert A, Bursavich M, Lombardi S, Georgiadis K, Reifenberg E, Flannery C, et al.
Bioorg Med Chem Lett
. 2008 Nov;
18(24):6454-7.
PMID: 18974001
N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared. Selected compounds 10, 14, 25, and 53 show sub-microM ADAMTS-5 potency and good selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP-13, and...
19.
Wu J, Liu W, Bemis A, Wang E, Qiu Y, Morris E, et al.
Arthritis Rheum
. 2007 Oct;
56(11):3675-84.
PMID: 17968891
Objective: To identify potential molecular mediators and biomarkers for osteoarthritis (OA), through comparative proteomic analysis of articular cartilage tissue obtained from normal donors without OA (n = 7) and patients...
20.
Bursavich M, Gilbert A, Lombardi S, Georgiadis K, Reifenberg E, Flannery C, et al.
Bioorg Med Chem Lett
. 2007 Sep;
17(20):5630-3.
PMID: 17804234
5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related...