Carl R Flannery
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Explore the profile of Carl R Flannery including associated specialties, affiliations and a list of published articles.
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39
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1664
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Recent Articles
21.
Gilbert A, Bursavich M, Lombardi S, Georgiadis K, Reifenberg E, Flannery C, et al.
Bioorg Med Chem Lett
. 2007 Jan;
17(5):1189-92.
PMID: 17210252
A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show microM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting...
22.
Bursavich M, Gilbert A, Lombardi S, Georgiadis K, Reifenberg E, Flannery C, et al.
Bioorg Med Chem Lett
. 2007 Jan;
17(5):1185-8.
PMID: 17210251
5-Benzylidene-2-thioxo-thiazolidin-4-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. The identified compounds show micromolar ADAMTS-5 potency and demonstrate SAR trends for both the aryl group and...
23.
Curtis C, Rees S, Cramp J, Flannery C, Hughes C, Little C, et al.
Proc Nutr Soc
. 2006 Dec;
65(4):434.
PMID: 17181911
No abstract available.
24.
Jones A, Gleghorn J, Hughes C, Fitz L, Zollner R, Wainwright S, et al.
J Orthop Res
. 2006 Nov;
25(3):283-92.
PMID: 17106881
Lubricin is a secreted, cytoprotective glycoprotein that contributes to the essential boundary lubrication mechanisms necessary for maintaining low friction levels at articular cartilage surfaces. Diminishment of lubricin function is thereby...
25.
Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans?
Flannery C
Arthritis Res Ther
. 2006 Mar;
8(2):106.
PMID: 16563183
Proteolytic degradation of articular cartilage macromolecules, including the large aggregating cartilage proteoglycan (aggrecan) and small leucine-rich proteoglycans (SLRPs), is a prominent pathophysiological feature of arthritic diseases such as osteoarthritis (OA)....
26.
Zeng W, Corcoran C, Collins-Racie L, Lavallie E, Morris E, Flannery C
Biochim Biophys Acta
. 2006 Mar;
1760(3):517-24.
PMID: 16507336
Aggrecanases are ADAMTS (a disintegrin and metalloproteinase with thrombospondin type I motifs) proteases capable of primary (patho)physiological cleavage at specific Glu-Xaa bonds within the core protein of the hyaluronan-binding proteoglycan...
27.
Young A, McLennan S, Smith M, Smith S, Cake M, Read R, et al.
Arthritis Res Ther
. 2006 Feb;
8(2):R41.
PMID: 16469119
Osteoarthritis is a disease of multifactorial aetiology characterised by progressive breakdown of articular cartilage. In the early stages of the disease, changes become apparent in the superficial zone of articular...
28.
Flannery C
Front Biosci
. 2005 Sep;
11:544-69.
PMID: 16146752
Members of the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin type I motifs) families of enzymes are capable of cleaving a diverse array of cellular, extracellular...
29.
Glasson S, Askew R, Sheppard B, Carito B, Blanchet T, Ma H, et al.
Nature
. 2005 Apr;
434(7033):644-8.
PMID: 15800624
Human osteoarthritis is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multifactorial, the cartilage destruction appears to be a result of...
30.
Chockalingam P, Zeng W, Morris E, Flannery C
Arthritis Rheum
. 2004 Oct;
50(9):2839-48.
PMID: 15457452
Objective: To determine whether aggrecanase (ADAMTS) activities in articular cartilage can directly lead to the release of hyaluronan (HA) and hyaladherins (aggrecan G1 domain and link proteins), as may occur...