Carl D Bortner
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Explore the profile of Carl D Bortner including associated specialties, affiliations and a list of published articles.
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53
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1425
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Recent Articles
1.
Kirkwood-Donelson K, Jarmusch A, Bortner C, Merrick B, Sinha B
Front Mol Biosci
. 2025 Feb;
11:1520876.
PMID: 39902375
Introduction: Ovarian cancer has been difficult to cure due to acquired or intrinsic resistance and therefore, newer or more effective drugs/approaches are needed for a successful treatment in the clinic....
2.
Sinha B, Murphy C, Brown S, Silver B, Tokar E, Bortner C
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201357
Erastin (ER) induces cell death through the formation of reactive oxygen species (ROS), resulting in ferroptosis. Ferroptosis is characterized by an accumulation of ROS within the cell, leading to an...
3.
Li H, Bradbury J, Edin M, Gruzdev A, Li H, Graves J, et al.
J Clin Invest
. 2024 Mar;
134(9).
PMID: 38483511
In lung, thromboxane A2 (TXA2) activates the TP receptor to induce proinflammatory and bronchoconstrictor effects. Thus, TP receptor antagonists and TXA2 synthase inhibitors have been tested as potential asthma therapeutics...
4.
Snyder B, Huang R, Burkholder A, Donahue D, Mahler B, Bortner C, et al.
Life Sci Alliance
. 2023 Oct;
7(1).
PMID: 37903626
Members of the tristetraprolin (TTP) family of RNA-binding proteins can bind to and promote the decay of specific transcripts containing AU-rich motifs. ZFP36 (TTP) is best known for regulating pro-inflammatory...
5.
Trempus C, Papas B, Sifre M, Bortner C, Scappini E, Tucker C, et al.
JCI Insight
. 2023 Oct;
8(22).
PMID: 37824216
Aberrant fibroblast function plays a key role in the pathogenesis of idiopathic pulmonary fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to lung injury. Platelet-derived growth factor...
6.
Sinha B, Bortner C, Jarmusch A, Tokar E, Murphy C, Wu X, et al.
Cells
. 2023 Jun;
12(12).
PMID: 37371096
Our recent studies show that the treatment of human ovarian tumor cells with NCX4040 results in significant depletions of cellular glutathione, the formation of reactive oxygen/nitrogen species and cell death....
7.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
8.
Inoue K, Bostan H, Browne M, Bevis O, Bortner C, Moore S, et al.
Sci Adv
. 2023 Feb;
9(7):eabq7744.
PMID: 36800423
mutations cause congenital arhinia (absent nose) and a muscular dystrophy called FSHD2. In FSHD2, loss of SMCHD1 repressive activity causes expression of double homeobox 4 (DUX4) in muscle tissue, where...
9.
Bortner C, Oakley R, Cidlowski J
Cell Death Discov
. 2022 Dec;
8(1):494.
PMID: 36539401
Bcl-2 is an anti-apoptotic protein that promotes cell survival and resistance to cell death. Predictably, Bcl-2 as well as other anti-apoptotic Bcl-2 family members have been found to be overexpressed...
10.
Sinha B, Tokar E, Bortner C
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955744
NCX4040, the non-steroidal anti-inflammatory-NO donor, is cytotoxic to several human tumors, including ovarian tumor cells. We have found that NCX4040 is also cytotoxic against both OVCAR-8 and its adriamycin resistant...