Calem Kenward
Overview
Explore the profile of Calem Kenward including associated specialties, affiliations and a list of published articles.
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11
Citations
108
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Recent Articles
1.
Kenward C, Vuckovic M, Paetzel M, Strynadka N
J Biol Chem
. 2024 May;
300(6):107367.
PMID: 38750796
The main protease (M) remains an essential therapeutic target for COVID-19 post infection intervention given its critical role in processing the majority of viral proteins encoded by the genome of...
2.
Perez-Vargas J, Worrall L, Olmstead A, Ton A, Lee J, Villanueva I, et al.
Emerg Microbes Infect
. 2023 Aug;
12(2):2246594.
PMID: 37555275
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and...
3.
Yu H, Worrall L, Berger T, Petric M, Lin B, Vuckovic M, et al.
J Immunol
. 2023 Jul;
211(6):981-993.
PMID: 37493438
Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the SARS-CoV-2 receptor-binding domain (RBD) is the immunodominant...
4.
Vergunst K, Kenward C, Langelaan D
Appl Microbiol Biotechnol
. 2022 Nov;
106(23):7831-7843.
PMID: 36329133
Hydrophobins are small proteins secreted by fungi that accumulate at interfaces, modify surface hydrophobicity, and self-assemble into large amyloid-like structures. These unusual properties make hydrophobins an attractive target for commercial...
5.
Lee J, Kenward C, Worrall L, Vuckovic M, Gentile F, Ton A, et al.
Nat Commun
. 2022 Sep;
13(1):5196.
PMID: 36057636
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or 16 non-structural proteins (nsp). Nsp5 is the main...
6.
Pazos M, Peters K, Boes A, Safaei Y, Kenward C, Caveney N, et al.
mBio
. 2020 Nov;
11(6).
PMID: 33144379
Sporulation-related repeat (SPOR) domains are present in many bacterial cell envelope proteins and are known to bind peptidoglycan. contains four SPOR proteins, DamX, DedD, FtsN, and RlpA, of which FtsN...
7.
Kenward C, Vergunst K, Langelaan D
Protein Expr Purif
. 2020 Sep;
176:105732.
PMID: 32866612
Hydrophobins are low molecular weight proteins secreted by fungi that are extremely surface-active and able to self-assemble into larger structures. Due to their unusual biochemical properties, hydrophobins are an attractive...
8.
Simmons J, Murza A, Lumsden M, Kenward C, Marsault E, Rainey J
Int J Mol Sci
. 2019 Jul;
20(15).
PMID: 31357423
To probe ligand-receptor binding at the atomic-level, a frequent approach involves multidimensional nuclear magnetic resonance (NMR) spectroscopy experiments relying on C- and/or N-enrichment alongside H. Alternatively, the lack of fluorine...
9.
Shin K, Kenward C, Rainey J
Compr Physiol
. 2018 Jan;
8(1):407-450.
PMID: 29357134
Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have been implicated in regulation of the adipoinsular axis,...
10.
Kenward C, Shin K, Rainey J
Chemistry
. 2018 Jan;
24(14):3391-3396.
PMID: 29342326
The strategy of applying fluorine NMR to characterize ligand binding to a membrane protein prepared with mixtures of tryptophans substituted with F at different positions on the indole ring was...