C W Porter
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Explore the profile of C W Porter including associated specialties, affiliations and a list of published articles.
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135
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1376
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Recent Articles
1.
Bistulfi G, Diegelman P, Foster B, Kramer D, Porter C, Smiraglia D
FASEB J
. 2009 May;
23(9):2888-97.
PMID: 19417083
Folate (vitamin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monophosphate (dTMP), which are required for methylation reactions and DNA synthesis, respectively. Folate depletion leads to an...
2.
Berger F, Kramer D, Porter C
Biochem Soc Trans
. 2007 Mar;
35(Pt 2):336-9.
PMID: 17371273
While polyamine homoeostasis is clearly important in maintenance of normal cell function, the roles of these cations, as well as the enzymes that regulate their metabolism, in the neoplastic process...
3.
Kramer D, Chang B, Chen Y, Diegelman P, Alm K, Black A, et al.
Cancer Res
. 2001 Nov;
61(21):7754-62.
PMID: 11691789
The cell cycle regulatory events that interface with polyamine requirements for cell growth have not yet been clearly identified. Here we use specific inhibitors of polyamine biosynthetic enzymes to investigate...
4.
Chen Y, Kramer D, Diegelman P, Vujcic S, Porter C
Cancer Res
. 2001 Aug;
61(17):6437-44.
PMID: 11522638
N(1),N(11)-Diethylnorspermine (DENSPM) is a polyamine analogue with clinicalrelevance as an experimental anticancer agent and the ability to elicit a profound apoptotic response in certain cell types. Here, we characterize the...
5.
Bras A, Janne J, Porter C, Sitar D
Drug Metab Dispos
. 2001 Apr;
29(5):676-80.
PMID: 11302933
Amantadine acetylation was demonstrated to occur both in vivo and in vitro using transgenic male mice overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT). We previously reported that neither NAT1 nor NAT2 was responsible...
6.
Korhonen V, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen J, et al.
Mol Pharmacol
. 2001 Feb;
59(2):231-8.
PMID: 11160858
Polyamines are known to be essential for normal cell growth and differentiation. However, despite numerous studies, specific cellular functions of polyamines in general and individual polyamines in particular have remained...
7.
Shi O, Morris Jr S, Zoghbi H, Porter C, OBrien W
Mol Cell Biol
. 2001 Jan;
21(3):811-3.
PMID: 11154268
Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in...
8.
Khomutov R, Zhukov I, Khomutov A, Khurs E, Kramer D, Miller J, et al.
Bioorg Khim
. 2000 Oct;
26(9):718-20.
PMID: 11036532
A phosphinic analogue of methionine bearing a phosphinic H(OH)(O)P fragment in place of the carboxyl group inhibited the growth of the L1210 cells and was intracellularly transformed to the phosphinic...
9.
Vujcic S, Halmekyto M, Diegelman P, Gan G, Kramer D, Janne J, et al.
J Biol Chem
. 2000 Sep;
275(49):38319-28.
PMID: 10978316
Acetylation of polyamines by spermidine/spermine N(1)-acetyltransferase (SSAT) has been implicated in their degradation and/or export out of the cell. The relationship of SSAT to polyamine pool dynamics and cell growth...
10.
Alm K, Berntsson P, Kramer D, Porter C, Oredsson S
Eur J Biochem
. 2000 Jun;
267(13):4157-64.
PMID: 10866819
When Chinese hamster ovary cells were seeded in the presence of the spermine analog N1,N11-diethylnorspermine (DENSPM), cell proliferation ceased; this was clearly apparent by cell counting 2 days after seeding...