C W Porter
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Explore the profile of C W Porter including associated specialties, affiliations and a list of published articles.
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135
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1376
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Recent Articles
11.
Dai H, Kramer D, Yang C, Murti K, Porter C, Cleveland J
Cancer Res
. 1999 Oct;
59(19):4944-54.
PMID: 10519408
Polyamine oxidase functions in the polyamine catabolic pathway, converting N1-acetyl-spermidine and -spermine into putrescine (Put) and spermidine (Spd), respectively, thereby facilitating homeostasis of intracellular polyamine pools. Inhibition of polyamine oxidase...
12.
Alhonen L, Pietila M, Halmekyto M, Kramer D, Janne J, Porter C
Mol Pharmacol
. 1999 Apr;
55(4):693-8.
PMID: 10101027
We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). These animals have now been tested...
13.
Kramer D, Vujcic S, Diegelman P, Alderfer J, Miller J, Black J, et al.
Cancer Res
. 1999 Mar;
59(6):1278-86.
PMID: 10096560
Although polyamines are well recognized for their critical involvement in cell growth, the cell cycle specificity of this requirement has not yet been characterized with respect to the newly delineated...
14.
Kramer D, Vujcic S, Diegelman P, White C, Black J, Porter C
Biochem Soc Trans
. 1999 Feb;
26(4):609-14.
PMID: 10047792
No abstract available.
15.
Suppola S, Pietila M, Parkkinen J, Korhonen V, Alhonen L, Halmekyto M, et al.
Biochem J
. 1999 Feb;
338 ( Pt 2):311-6.
PMID: 10024505
We recently generated a transgenic mouse line overexpressing spermidine/spermine N1-acetyltransferase (SSAT) gene under its own promoter. The tissue polyamine pools of these animals were profoundly affected and the mice were...
16.
Kramer D, Black J, Mett H, Bergeron R, Porter C
Cancer Res
. 1998 Sep;
58(17):3883-90.
PMID: 9731498
CGP-48664, an inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), is presently undergoing Phase 1 clinical trials as an experimental anticancer agent. We have shown previously (D. L. Kramer...
17.
Felschow D, Mi Z, Stanek J, Frei J, Porter C
Biochem J
. 1998 Feb;
328 ( Pt 3):889-95.
PMID: 9396735
Polyamine transport is an active process which contributes to the regulation and maintenance of intracellular polyamine pools. Although the biochemical properties of polyamine transport in mammalian cells have been extensively...
18.
Alhonen L, Karppinen A, Uusi-Oukari M, Vujcic S, Korhonen V, Halmekyto M, et al.
J Biol Chem
. 1998 Jan;
273(4):1964-9.
PMID: 9442032
A recently generated transgenic mouse line having activated polyamine catabolism due to systemic overexpression of spermidine/spermine N1-acetyltransferase (SSAT) was used to isolate primary fetal fibroblasts as a means to further...
19.
Mi Z, Kramer D, Miller J, Bergeron R, Bernacki R, Porter C
Prostate
. 1998 Jan;
34(1):51-60.
PMID: 9428388
Background: The possibility was investigated that complex homeostatic mechanisms which maintain polyamine pools in prostate-derived tumors may differ from those which are typically seen in other tissues and tumors. Methods:...
20.
Kramer D, Fogel-Petrovic M, Diegelman P, Cooley J, Bernacki R, McManis J, et al.
Cancer Res
. 1998 Jan;
57(24):5521-7.
PMID: 9407962
On the basis of encouraging preclinical findings, polyamine analogues have emerged as a novel class of experimental antitumor agents. The spermine derivative N1,N11-diethylnorspermine (DE-333, also known as DENSPM) is currently...