Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2001 Jan 12

PMID 11154268

Citations 72

Authors

O Shi

S M Morris Jr

H Zoghbi

C W Porter

W E OBrien

Affiliations

Soon will be listed here.

Abstract

Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of this enzyme. Homozygous arginase II-deficient mice were viable and apparently indistinguishable from wild-type mice, except for an elevated plasma arginine level which indicates that arginase II plays an important role in arginine homeostasis.

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